› 6ltn

Electron Microscopy
3.1Å resolution

cryo-EM structure of C-terminal truncated human Pannexin1

Released:
DOI: 10.2210/pdb6ltn/pdb
PDB entry 6ltn coloured by chain, front view.
PDB entry 6ltn coloured by chain, side view.
PDB entry 6ltn coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural basis for gating mechanism of Pannexin 1 channel.
Mou L, Ke M, Song M, Shan Y, Xiao Q, Liu Q, Li J, Sun K, Pu L, Guo L, Geng J, Wu J, Deng D
Cell Res 30 452-454 (2020)
PMID: 32284561
Related structures: EMD-0975

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo heptamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-188716 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Pannexin-1 Chains: A, B, C, D, E, F, G
Molecule details ›
Chains: A, B, C, D, E, F, G
Length: 436 amino acids
Theoretical weight: 49.38 KDa
Source organism: Homo sapiens
Expression system: Insect cell expression vector pTIE1
UniProt:
  • Canonical: Q96RD7 (Residues: 1-426; Coverage: 100%)
Gene names: MRS1, PANX1, UNQ2529/PRO6028
Sequence domains: Innexin

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.1Å
Relevant EMDB volumes: EMD-0975
Expression system: Insect cell expression vector pTIE1

Quick links

Citations

6 review citations

Human Pannexin 1 channel: Insight in structure-function mechanism and its potential physiological roles.
Bhat et al. (2021)
5 more

3 mentions without citation

On the molecular nature of large-pore channels.
Syrjanen et al. (2021)
2 more