6lx3

Electron Microscopy
3.15Å resolution

Cryo-EM structure of human secretory immunoglobulin A

Released:
Source organism: Homo sapiens
Related structures: EMD-30004

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero hexamer (preferred)
PDBe Complex ID:
PDB-CPX-134432 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
Immunoglobulin heavy constant alpha 1; Interleukin-2 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 291 amino acids
Theoretical weight: 31.45 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P60568 (Residues: 1-21; Coverage: 1%)
  • Canonical: P01876 (Residues: 122-333; Coverage: 53%)
Gene names: IGHA1, IL2
Sequence domains:
Immunoglobulin J chain Chain: J
Molecule details ›
Chain: J
Length: 167 amino acids
Theoretical weight: 19.23 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P01591 (Residues: 1-159; Coverage: 100%)
Gene names: IGCJ, IGJ, JCHAIN
Sequence domains: Immunoglobulin J chain
Secretory component Chain: P
Molecule details ›
Chain: P
Length: 573 amino acids
Theoretical weight: 63.31 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P01833 (Residues: 1-565; Coverage: 73%)
Gene name: PIGR
Sequence domains: Immunoglobulin V-set domain

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.15Å
Relevant EMDB volumes: EMD-30004
Expression system: Homo sapiens