› 6m04

Electron Microscopy
4.36Å resolution

Structure of the human homo-hexameric LRRC8D channel at 4.36 Angstroms

Released:
DOI: 10.2210/pdb6m04/pdb
PDB entry 6m04 coloured by chain, front view.
PDB entry 6m04 coloured by chain, side view.
PDB entry 6m04 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Cryo-EM structure of the volume-regulated anion channel LRRC8D isoform identifies features important for substrate permeation.
Nakamura R, Numata T, Kasuya G, Yokoyama T, Nishizawa T, Kusakizako T, Kato T, Hagino T, Dohmae N, Inoue M, Watanabe K, Ichijo H, Kikkawa M, Shirouzu M, Jentsch TJ, Ishitani R, Okada Y, Nureki O
Commun Biol 3 240 (2020)
PMID: 32415200
Related structures: EMD-30029

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo hexamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-181623 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Volume-regulated anion channel subunit LRRC8D Chains: A, B, C, D, E, F
Molecule details ›
Chains: A, B, C, D, E, F
Length: 866 amino acids
Theoretical weight: 99.31 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q7L1W4 (Residues: 1-858; Coverage: 100%)
Gene names: LRRC5, LRRC8D, UNQ213/PRO239
Sequence domains:

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 4.36Å
Relevant EMDB volumes: EMD-30029
Expression system: Homo sapiens

Quick links

Citations

8 review citations

The Relationship Between Actin Cytoskeleton and Membrane Transporters in Cisplatin Resistance of Cancer Cells.
Shimizu et al. (2020)
7 more

5 mentions without citation

On the molecular nature of large-pore channels.
Syrjanen et al. (2021)
4 more