› 6m3m

X-ray diffraction
2.7Å resolution

Crystal structure of SARS-CoV-2 nucleocapsid protein N-terminal RNA binding domain

Released:
DOI: 10.2210/pdb6m3m/pdb
PDB entry 6m3m coloured by chain, front view.
PDB entry 6m3m coloured by chain, side view.
PDB entry 6m3m coloured by chain, top view.
Source organism: Severe acute respiratory syndrome coronavirus 2
Primary publication:
Crystal structure of SARS-CoV-2 nucleocapsid protein RNA binding domain reveals potential unique drug targeting sites.
Kang S, Yang M, Hong Z, Zhang L, Huang Z, Chen X, He S, Zhou Z, Zhou Z, Chen Q, Yan Y, Zhang C, Shan H, Chen S
Acta Pharm Sin B 10 1228-1238 (2020)
PMID: 32363136

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-144998 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Nucleoprotein Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 136 amino acids
Theoretical weight: 14.89 KDa
Source organism: Severe acute respiratory syndrome coronavirus 2
Expression system: Escherichia coli
UniProt:
  • Canonical: P0DTC9 (Residues: 41-174; Coverage: 32%)
Gene name: N
Sequence domains: Coronavirus nucleocapsid

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU
Spacegroup: P212121
Unit cell:
a: 58.888Å b: 92.685Å c: 97.325Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.258 0.258 0.293
Expression system: Escherichia coli

Quick links

Citations

85 review citations

The Natural History, Pathobiology, and Clinical Manifestations of SARS-CoV-2 Infections.
Machhi et al. (2020)
84 more

150 mentions without citation

COVID-19: Drug Targets and Potential Treatments.
Gil et al. (2020)
149 more