› 6m66

Electron Microscopy
4.1Å resolution

The Cryo-EM Structure of Human Pannexin 1

Released:
DOI: 10.2210/pdb6m66/pdb
PDB entry 6m66 coloured by chain, front view.
PDB entry 6m66 coloured by chain, side view.
PDB entry 6m66 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Cryo-EM structures of human pannexin 1 channel.
Jin Q, Zhang B, Zheng X, Li N, Xu L, Xie Y, Song F, Bhat EA, Chen Y, Gao N, Guo J, Zhang X, Ye S
Cell Res 30 449-451 (2020)
PMID: 32246089
Related structures: EMD-30114

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo heptamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-188716 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Pannexin-1 Chains: A, B, C, D, E, F, G
Molecule details ›
Chains: A, B, C, D, E, F, G
Length: 440 amino acids
Theoretical weight: 49.76 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q96RD7 (Residues: 1-426; Coverage: 100%)
Gene names: MRS1, PANX1, UNQ2529/PRO6028
Sequence domains: Innexin

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 4.1Å
Relevant EMDB volumes: EMD-30114
Expression system: Homo sapiens

Quick links

Citations

6 review citations

Recent advances in connexin gap junction biology.
Lampe et al. (2022)
5 more

5 mentions without citation

On the molecular nature of large-pore channels.
Syrjanen et al. (2021)
4 more