› 6maj

X-ray diffraction
2.14Å resolution

Function and Biology Details

Reaction catalysed: 
Acetyl-CoA + [protein]-L-lysine = CoA + [protein]-N(6)-acetyl-L-lysine
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-131866 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Histone acetyltransferase KAT7 Chain: A
Molecule details ›
Chain: A
Length: 279 amino acids
Theoretical weight: 32.87 KDa
Source organism: Homo sapiens
Expression system: unidentified baculovirus
UniProt:
  • Canonical: O95251 (Residues: 336-609; Coverage: 45%)
Gene names: HBO1, HBOa, KAT7, MYST2
Sequence domains:
Bromodomain-containing protein 1 Chain: B
Molecule details ›
Chain: B
Length: 52 amino acids
Theoretical weight: 5.84 KDa
Source organism: Homo sapiens
Expression system: unidentified baculovirus
UniProt:
  • Canonical: O95696 (Residues: 31-80; Coverage: 5%)
Gene names: BRD1, BRL, BRPF2

Ligands and Environments

3 bound ligands:
Ligand ZN 1 x ZN
Ligand GOL 2 x GOL
Ligand JAV 1 x JAV
1 modified residue:
Ligand ALY 1 x ALY

Experiments and Validation Details

Entry percentile scores
X-ray source: AUSTRALIAN SYNCHROTRON BEAMLINE MX2
Spacegroup: R3
Unit cell:
a: 111.543Å b: 111.543Å c: 73.702Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.197 0.195 0.237
Expression system: unidentified baculovirus

Quick links

Citations

19 review citations

Non-genetic mechanisms of therapeutic resistance in cancer.
Marine et al. (2020)
18 more

1 mention without citation

Inhibition of PfMYST Histone Acetyltransferase Activity Blocks Plasmodium falciparum Growth and Survival.
Sen et al. (2020)