› 6mak

X-ray diffraction
2.13Å resolution

Function and Biology Details

Reaction catalysed: 
Acetyl-CoA + [protein]-L-lysine = CoA + [protein]-N(6)-acetyl-L-lysine
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-131866 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Histone acetyltransferase KAT7 Chain: A
Molecule details ›
Chain: A
Length: 279 amino acids
Theoretical weight: 32.87 KDa
Source organism: Homo sapiens
Expression system: unidentified baculovirus
UniProt:
  • Canonical: O95251 (Residues: 336-609; Coverage: 45%)
Gene names: HBO1, HBOa, KAT7, MYST2
Sequence domains:
Bromodomain-containing protein 1 Chain: B
Molecule details ›
Chain: B
Length: 52 amino acids
Theoretical weight: 5.84 KDa
Source organism: Homo sapiens
Expression system: unidentified baculovirus
UniProt:
  • Canonical: O95696 (Residues: 31-80; Coverage: 5%)
Gene names: BRD1, BRL, BRPF2

Ligands and Environments


Cofactor: Ligand ACO 1 x ACO
1 bound ligand:
Ligand ZN 1 x ZN
1 modified residue:
Ligand ALY 1 x ALY

Experiments and Validation Details

Entry percentile scores
X-ray source: AUSTRALIAN SYNCHROTRON BEAMLINE MX2
Unit cell:
a: 87.628Å b: 39.026Å c: 107.765Å
α: 90° β: 99.59° γ: 90°
R-values:
R R work R free
0.216 0.214 0.264
Expression system: unidentified baculovirus

Quick links

Citations

19 review citations

Non-genetic mechanisms of therapeutic resistance in cancer.
Marine et al. (2020)
18 more