› 6mgn

X-ray diffraction
1.9Å resolution

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-147536 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Transcription factor E2-alpha Chain: A
Molecule details ›
Chain: A
Length: 52 amino acids
Theoretical weight: 6.14 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P15923 (Residues: 561-612; Coverage: 8%)
Gene names: BHLHB21, E2A, ITF1, TCF3
Sequence domains: Helix-loop-helix DNA-binding domain
DNA-binding protein inhibitor ID-1 Chain: B
Molecule details ›
Chain: B
Length: 47 amino acids
Theoretical weight: 5.58 KDa
Source organism: Mus musculus
Expression system: Escherichia coli
UniProt:
  • Canonical: P20067 (Residues: 58-104; Coverage: 28%)
Gene names: Id, Id-1, Id1, Idb1
Sequence domains: Helix-loop-helix DNA-binding domain

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X9A
Spacegroup: P42212
Unit cell:
a: 54.962Å b: 54.962Å c: 81.94Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.186 0.183 0.218
Expression system: Escherichia coli

Quick links

Citations

5 review citations

Biological drug therapy for ocular angiogenesis: Anti-VEGF agents and novel strategies based on nanotechnology.
Formica et al. (2021)
4 more

3 mentions without citation

Homodimeric and Heterodimeric Interactions among Vertebrate Basic Helix-Loop-Helix Transcription Factors.
Torres-Machorro AL. (2021)
2 more