› 6mq5

X-ray diffraction
2.15Å resolution

Structure of human CLASP1 TOG1

Released:
DOI: 10.2210/pdb6mq5/pdb
PDB entry 6mq5 coloured by chain, front view.
PDB entry 6mq5 coloured by chain, side view.
PDB entry 6mq5 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structures of TOG1 and TOG2 from the human microtubule dynamics regulator CLASP1.
Leano JB, Slep KC
PLoS One 14 e0219823 (2019)
PMID: 31323070

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-182265 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
CLIP-associating protein 1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 257 amino acids
Theoretical weight: 29.02 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q7Z460 (Residues: 1-257; Coverage: 17%)
Gene names: CLASP1, KIAA0622, MAST1
Sequence domains: HEAT repeat

Ligands and Environments

No bound ligands
1 modified residue:
Ligand MSE 14 x MSE

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 22-ID
Spacegroup: P21
Unit cell:
a: 40.975Å b: 114.022Å c: 46.649Å
α: 90° β: 99.85° γ: 90°
R-values:
R R work R free
0.195 0.19 0.244
Expression system: Escherichia coli

Quick links

Citations

3 review citations

Regulation of microtubule dynamics, mechanics and function through the growing tip.
Gudimchuk et al. (2021)
2 more

1 mention without citation

Structures of TOG1 and TOG2 from the human microtubule dynamics regulator CLASP1.
Leano et al. (2019)