› 6mu2

Electron Microscopy
3.9Å resolution

Structure of full-length IP3R1 channel in the Apo-state

Released:
DOI: 10.2210/pdb6mu2/pdb
PDB entry 6mu2 coloured by chain, front view.
PDB entry 6mu2 coloured by chain, side view.
PDB entry 6mu2 coloured by chain, top view.
Source organism: Rattus norvegicus
Primary publication:
Cryo-EM reveals ligand induced allostery underlying InsP3R channel gating.
Fan G, Baker MR, Wang Z, Seryshev AB, Ludtke SJ, Baker ML, Serysheva II
Cell Res 28 1158-1170 (2018)
PMID: 30470765
Related structures: EMD-9244

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-151603 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Inositol 1,4,5-trisphosphate-gated calcium channel ITPR1 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 2750 amino acids
Theoretical weight: 313.66 KDa
Source organism: Rattus norvegicus
UniProt:
  • Canonical: P29994 (Residues: 1-2750; Coverage: 100%)
Gene names: Insp3r, Itpr1
Sequence domains:

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.9Å
Relevant EMDB volumes: EMD-9244

Quick links

Citations

8 review citations

Fundamentals of Cellular Calcium Signaling: A Primer.
Bootman et al. (2020)
7 more

3 mentions without citation

Cryo-EM reveals ligand induced allostery underlying InsP3R channel gating.
Fan et al. (2018)
2 more