› 6mv6

X-ray diffraction
1.5Å resolution

Crystal structure of RNAse 6

Released:
DOI: 10.2210/pdb6mv6/pdb
PDB entry 6mv6 coloured by chain, front view.
PDB entry 6mv6 coloured by chain, side view.
PDB entry 6mv6 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Insights into Structural and Dynamical Changes Experienced by Human RNase 6 upon Ligand Binding.
Narayanan C, Bernard DN, Létourneau M, Gagnon J, Gagné D, Bafna K, Calmettes C, Couture JF, Agarwal PK, Doucet N
Biochemistry 59 755-765 (2020)
PMID: 31909602

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-187981 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Ribonuclease K6 Chain: A
Molecule details ›
Chain: A
Length: 126 amino acids
Theoretical weight: 14.46 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q93091 (Residues: 26-150; Coverage: 98%)
Gene names: RNASE6, RNS6
Sequence domains: Pancreatic ribonuclease

Ligands and Environments

1 bound ligand:
Ligand PO4 3 x PO4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 17-ID
Unit cell:
a: 27.83Å b: 38.78Å c: 108.53Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.172 0.169 0.227
Expression system: Escherichia coli

Quick links

Citations

3 citation in other articles

A Common Polymorphism in RNASE6 Impacts Its Antimicrobial Activity toward Uropathogenic Escherichia coli.
Anguita et al. (2024)
2 more

2 mentions without citation

The role of human ribonuclease A family in health and diseases: A systematic review.
Sun et al. (2022)
1 more