› 6mvl

X-ray diffraction
1.61Å resolution

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-212733 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
V-type immunoglobulin domain-containing suppressor of T-cell activation Chain: A
Molecule details ›
Chain: A
Length: 169 amino acids
Theoretical weight: 19.1 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9H7M9 (Residues: 32-194; Coverage: 58%)
Gene names: C10orf54, PP2135, SISP1, UNQ730/PRO1412, VISTA, VSIR
Sequence domains: Immunoglobulin V-set domain
Antibody Fab fragment heavy chain Chain: H
Molecule details ›
Chain: H
Length: 229 amino acids
Theoretical weight: 24.37 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
Antibody Fab fragment light chain Chain: L
Molecule details ›
Chain: L
Length: 215 amino acids
Theoretical weight: 23.36 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens

Ligands and Environments

2 bound ligands:
Ligand NAG 1 x NAG
Ligand SO4 14 x SO4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 17-ID
Spacegroup: I212121
Unit cell:
a: 66.166Å b: 125.856Å c: 192.04Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.184 0.182 0.225
Expression systems:
  • Escherichia coli
  • Homo sapiens

Quick links

Citations

79 review citations

Revisiting Immunotherapy: A Focus on Prostate Cancer.
Cha et al. (2020)
78 more

1 mention without citation

VISTA: A Mediator of Quiescence and a Promising Target in Cancer Immunotherapy.
Yuan et al. (2021)