› 6n0b

X-ray diffraction
1.74Å resolution

Structure of GTPase Domain of Human Septin 7 at High Resolution

Released:
DOI: 10.2210/pdb6n0b/pdb
PDB entry 6n0b coloured by chain, front view.
PDB entry 6n0b coloured by chain, side view.
PDB entry 6n0b coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Revisiting SEPT7 and the slippage of β-strands in the septin family.
Brognara G, Pereira HM, Brandão-Neto J, Araujo APU, Garratt RC
J Struct Biol 207 67-73 (2019)
PMID: 31009756

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-172448 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Septin-7 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 285 amino acids
Theoretical weight: 32.76 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q16181 (Residues: 48-318; Coverage: 62%)
Gene names: CDC10, SEPT7, SEPTIN7
Sequence domains: Septin

Ligands and Environments

1 bound ligand:
Ligand GDP 4 x GDP
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I24
Spacegroup: C2
Unit cell:
a: 151.513Å b: 68.866Å c: 150.519Å
α: 90° β: 112.76° γ: 90°
R-values:
R R work R free
0.175 0.174 0.203
Expression system: Escherichia coli

Quick links

Citations

1 citations in other articles

A complete compendium of crystal structures for the human SEPT3 subgroup reveals functional plasticity at a specific septin interface.
Castro et al. (2020)

3 mentions without citation

The Structural Biology of Septins and Their Filaments: An Update.
Cavini et al. (2021)
2 more