› 6n0m

X-ray diffraction
3.3Å resolution

CRYSTAL STRUCTURE OF SESTRIN2 IN COMPLEX WITH NV-0005138

Released:
DOI: 10.2210/pdb6n0m/pdb
PDB entry 6n0m coloured by chain, front view.
PDB entry 6n0m coloured by chain, side view.
PDB entry 6n0m coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Discovery of NV-5138, the first selective Brain mTORC1 activator.
Sengupta S, Giaime E, Narayan S, Hahm S, Howell J, O'Neill D, Vlasuk GP, Saiah E
Sci Rep 9 4107 (2019)
PMID: 30858438

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-157638 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Sestrin-2 Chains: A, B, C, D, E
Molecule details ›
Chains: A, B, C, D, E
Length: 415 amino acids
Theoretical weight: 47.46 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P58004 (Residues: 66-480; Coverage: 87%)
Gene names: Hi95, SESN2, SEST2
Sequence domains: PA26 p53-induced protein (sestrin)

Ligands and Environments

1 bound ligand:
Ligand K94 5 x K94
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: CLSI BEAMLINE 08ID-1
Spacegroup: I23
Unit cell:
a: 290.41Å b: 290.41Å c: 290.41Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.187 0.184 0.25
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

12 review citations

Novel Glutamatergic Modulators for the Treatment of Mood Disorders: Current Status.
Henter et al. (2021)
11 more