› 6n1g

X-ray diffraction
4Å resolution

Crystal structure of Aquaglyceroporin AQP7

Released:
DOI: 10.2210/pdb6n1g/pdb
PDB entry 6n1g coloured by chain, front view.
PDB entry 6n1g coloured by chain, side view.
PDB entry 6n1g coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Aquaporin-7: A Dynamic Aquaglyceroporin With Greater Water and Glycerol Permeability Than Its Bacterial Homolog GlpF.
Moss FJ, Mahinthichaichan P, Lodowski DT, Kowatz T, Tajkhorshid E, Engel A, Boron WF, Vahedi-Faridi A
Front Physiol 11 728 (2020)
PMID: 32695023

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-126992 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Aquaporin-7 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 376 amino acids
Theoretical weight: 41.1 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: O14520 (Residues: 1-342; Coverage: 100%)
Gene names: AQP7, AQP7L, AQP9
Sequence domains: Major intrinsic protein

Ligands and Environments

1 bound ligand:
Ligand GOL 12 x GOL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 24-ID-C
Spacegroup: F4132
Unit cell:
a: 385.658Å b: 385.658Å c: 385.658Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.233 0.232 0.277
Expression system: Spodoptera frugiperda

Quick links

Citations

3 review citations

Carbon dioxide transport across membranes.
Michenkova et al. (2021)
2 more

2 mentions without citation

Aquaporin Gating: A New Twist to Unravel Permeation through Water Channels.
Ozu et al. (2022)
1 more