› 6n29

X-ray diffraction
2.5Å resolution

Crystal structure of monomeric von Willebrand Factor D`D3 assembly

Released:
DOI: 10.2210/pdb6n29/pdb
PDB entry 6n29 coloured by chain, front view.
PDB entry 6n29 coloured by chain, side view.
PDB entry 6n29 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
The von Willebrand factor D'D3 assembly and structural principles for factor VIII binding and concatemer biogenesis.
Dong X, Leksa NC, Chhabra ES, Arndt JW, Lu Q, Knockenhauer KE, Peters RT, Springer TA
Blood 133 1523-1533 (2019)
PMID: 30642920

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-137563 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
von Willebrand factor Chains: A, B
Molecule details ›
Chains: A, B
Length: 483 amino acids
Theoretical weight: 53.33 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P04275 (Residues: 764-1244; Coverage: 17%)
Gene names: F8VWF, VWF
Sequence domains:

Ligands and Environments

3 bound ligands:
Ligand NAG 5 x NAG
Ligand CA 3 x CA
Ligand PEG 2 x PEG
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 31-ID
Spacegroup: P43212
Unit cell:
a: 174.69Å b: 174.69Å c: 104.62Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.203 0.202 0.242
Expression system: Homo sapiens

Quick links

Citations

3 review citations

Mucins and the Microbiome.
Hansson GC. (2020)
2 more

20 mentions without citation

Engineered Molecular Therapeutics Targeting Fibrin and the Coagulation System: a Biophysical Perspective.
Risser et al. (2022)
19 more