› 6n8c

Solution NMR

Structure of the Huntingtin tetramer/dimer mixture determined by paramagnetic NMR

Released:
DOI: 10.2210/pdb6n8c/pdb
PDB entry 6n8c coloured by chain, ensemble of 10 models, front view.
PDB entry 6n8c coloured by chain, ensemble of 10 models, side view.
PDB entry 6n8c coloured by chain, ensemble of 10 models, top view.
Source organism: Homo sapiens
Primary publication:
Probing initial transient oligomerization events facilitating Huntingtin fibril nucleation at atomic resolution by relaxation-based NMR.
Kotler SA, Tugarinov V, Schmidt T, Ceccon A, Libich DS, Ghirlando R, Schwieters CD, Clore GM
Proc Natl Acad Sci U S A 116 3562-3571 (2019)
PMID: 30808748

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-154900 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Huntingtin Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 23 amino acids
Theoretical weight: 2.74 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P42858 (Residues: 2-24; Coverage: 1%)
Gene names: HD, HTT, IT15

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 3%
Refinement method: simulated annealing
Expression system: Escherichia coli

Quick links

Citations

5 review citations

NMR illuminates intrinsic disorder.
Dyson et al. (2021)
4 more

1 mention without citation

Probing initial transient oligomerization events facilitating Huntingtin fibril nucleation at atomic resolution by relaxation-based NMR.
Kotler et al. (2019)