› 6n8q

X-ray diffraction
2.2Å resolution

Crystal structure of the human cell polarity protein Lethal Giant Larvae 2 (Lgl2). Unphosphorylated, crystal form 2.

Released:
DOI: 10.2210/pdb6n8q/pdb
PDB entry 6n8q coloured by chain, front view.
PDB entry 6n8q coloured by chain, side view.
PDB entry 6n8q coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural insights into the aPKC regulatory switch mechanism of the human cell polarity protein lethal giant larvae 2.
Almagor L, Ufimtsev IS, Ayer A, Li J, Weis WI
Proc Natl Acad Sci U S A 116 10804-10812 (2019)
PMID: 31088962

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-180102 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
LLGL scribble cell polarity complex component 2 Chain: A
Molecule details ›
Chain: A
Length: 979 amino acids
Theoretical weight: 109.28 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q6P1M3 (Residues: 12-978; Coverage: 95%)
Gene name: LLGL2
Sequence domains:

Ligands and Environments

2 bound ligands:
Ligand CL 1 x CL
Ligand GOL 1 x GOL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRL BEAMLINE BL12-2
Spacegroup: C2
Unit cell:
a: 174.528Å b: 46.759Å c: 137.689Å
α: 90° β: 116° γ: 90°
R-values:
R R work R free
0.207 0.206 0.226
Expression system: Spodoptera frugiperda

Quick links

Citations

1 review citation

Inter-Species Rescue of Mutant Phenotype-The Standard for Genetic Analysis of Human Genetic Disorders in Drosophila melanogaster Model.
Ecovoiu et al. (2022)
5 other articles

1 mention without citation

Structural insights into the aPKC regulatory switch mechanism of the human cell polarity protein lethal giant larvae 2.
Almagor et al. (2019)