› 6ng3

X-ray diffraction
2.88Å resolution

Crystal structure of human CD160 and HVEM complex

Released:
DOI: 10.2210/pdb6ng3/pdb
PDB entry 6ng3 coloured by chain, front view.
PDB entry 6ng3 coloured by chain, side view.
PDB entry 6ng3 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural Basis of CD160:HVEM Recognition.
Liu W, Garrett SC, Fedorov EV, Ramagopal UA, Garforth SJ, Bonanno JB, Almo SC
Structure 27 1286-1295.e4 (2019)
PMID: 31230945

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-132092 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecules (3 distinct):
CD160 antigen; Tumor necrosis factor receptor superfamily member 14 Chain: A
Molecule details ›
Chain: A
Length: 250 amino acids
Theoretical weight: 26.31 KDa
Source organism: Homo sapiens
Expression system: Drosophila acanthoptera
UniProt:
  • Canonical: O95971 (Residues: 27-144; Coverage: 75%)
  • Canonical: Q92956 (Residues: 39-143; Coverage: 43%)
Gene names: BY55, CD160, HVEA, HVEM, TNFRSF14, UNQ329/PRO509
Sequence domains: TNFR/NGFR cysteine-rich region

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG, BMA
Carbohydrate polymer
Carbohydrate polymer : NEW Components: NAG
Carbohydrate polymer
1 bound ligand:
Ligand MG 1 x MG
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 31-ID
Spacegroup: I4122
Unit cell:
a: 87.93Å b: 87.93Å c: 157.698Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.236 0.234 0.274
Expression system: Drosophila acanthoptera

Quick links

Citations

6 review citations

Targeting the ubiquitination/deubiquitination process to regulate immune checkpoint pathways.
Liu et al. (2021)
5 more

6 mentions without citation

Structural Basis of CD160:HVEM Recognition.
Liu et al. (2019)
5 more