› 6nhw

Solution NMR

Structure of the transmembrane domain of the Death Receptor 5 - Dimer of Trimer

Released:
DOI: 10.2210/pdb6nhw/pdb
PDB entry 6nhw coloured by chain, ensemble of 15 models, front view.
PDB entry 6nhw coloured by chain, ensemble of 15 models, side view.
PDB entry 6nhw coloured by chain, ensemble of 15 models, top view.
Source organism: Homo sapiens
Primary publication:
Higher-Order Clustering of the Transmembrane Anchor of DR5 Drives Signaling.
Pan L, Fu TM, Zhao W, Zhao L, Chen W, Qiu C, Liu W, Liu Z, Piai A, Fu Q, Chen S, Wu H, Chou JJ
Cell 176 1477-1489.e14 (2019)
PMID: 30827683

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo hexamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-127109 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Tumor necrosis factor receptor superfamily member 10B Chains: A, B, C, D, E, F
Molecule details ›
Chains: A, B, C, D, E, F
Length: 36 amino acids
Theoretical weight: 3.73 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: O14763 (Residues: 208-242; Coverage: 9%)
Gene names: DR5, KILLER, TNFRSF10B, TRAILR2, TRICK2, UNQ160/PRO186, ZTNFR9

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 5%
Refinement method: simulated annealing
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

14 review citations

Importance of TRAIL Molecular Anatomy in Receptor Oligomerization and Signaling. Implications for Cancer Therapy.
Naval et al. (2019)
13 more

4 mentions without citation

Solution NMR: A powerful tool for structural and functional studies of membrane proteins in reconstituted environments.
Puthenveetil et al. (2019)
3 more