› 6nig

X-ray diffraction
2.35Å resolution

Crystal structure of the human TLR2-Diprovocim complex

Released:
DOI: 10.2210/pdb6nig/pdb
PDB entry 6nig coloured by chain, front view.
PDB entry 6nig coloured by chain, side view.
PDB entry 6nig coloured by chain, top view.
Source organisms:
Primary publication:
Structural Basis of TLR2/TLR1 Activation by the Synthetic Agonist Diprovocim.
Su L, Wang Y, Wang J, Mifune Y, Morin MD, Jones BT, Moresco EMY, Boger DL, Beutler B, Zhang H
J Med Chem 62 2938-2949 (2019)
PMID: 30829478

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-130042 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecules (2 distinct):
LRRNT domain-containing protein; Toll-like receptor 2 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 576 amino acids
Theoretical weight: 65.28 KDa
Source organisms: Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: O60603 (Residues: 1-507; Coverage: 64%)
  • Canonical: Q2YE02 (Residues: 181-248; Coverage: 23%)
Gene names: TIL4, TLR2, VLRB
Sequence domains:

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG
Carbohydrate polymer
2 bound ligands:
Ligand KQD 4 x KQD
Ligand NAG 9 x NAG
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 19-ID
Spacegroup: P21
Unit cell:
a: 66.098Å b: 201.252Å c: 109.359Å
α: 90° β: 94.26° γ: 90°
R-values:
R R work R free
0.21 0.21 0.236
Expression system: Spodoptera frugiperda

Quick links

Citations

9 review citations

Pattern recognition receptors in health and diseases.
Li et al. (2021)
8 more

39 mentions without citation

Structural and functional understanding of the toll-like receptors.
Asami et al. (2021)
38 more