› 6nmy

X-ray diffraction
3.3Å resolution

A Cytokine-receptor complex

Released:
DOI: 10.2210/pdb6nmy/pdb
PDB entry 6nmy coloured by chain, front view.
PDB entry 6nmy coloured by chain, side view.
PDB entry 6nmy coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Dhagat U, Kan WL, Hercus TR, Broughton SE, Nero TL, Lopez AF, Parker MW

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero tetramer (preferred)
PDBe Complex ID:
PDB-CPX-140302 (preferred)
Entry contents:
4 distinct polypeptide molecules
Macromolecules (7 distinct):
Interleukin-3 receptor subunit alpha Chains: F, M
Molecule details ›
Chains: F, M
Length: 288 amino acids
Theoretical weight: 33.23 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P26951 (Residues: 20-307; Coverage: 80%)
Gene names: IL3R, IL3RA
Sequence domains:
Cytokine receptor common subunit beta Chains: A, C
Molecule details ›
Chains: A, C
Length: 216 amino acids
Theoretical weight: 24.59 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P32927 (Residues: 25-240; Coverage: 25%)
Gene names: CSF2RB, IL3RB, IL5RB
Sequence domains: GM-CSF/IL-3/IL-5 receptor common beta subunit, N-terminal
Interleukin-3 Chains: I, J
Molecule details ›
Chains: I, J
Length: 118 amino acids
Theoretical weight: 13.38 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli K-12
UniProt:
  • Canonical: P08700 (Residues: 31-144; Coverage: 86%)
Gene name: IL3
Sequence domains: Interleukin-3
Cytokine receptor common subunit beta Chains: B, D
Molecule details ›
Chains: B, D
Length: 198 amino acids
Theoretical weight: 22.69 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P32927 (Residues: 241-438; Coverage: 23%)
Gene names: CSF2RB, IL3RB, IL5RB

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG, BMA, FUC
Carbohydrate polymer
Carbohydrate polymer : NEW Components: NAG, BMA
Carbohydrate polymer
Carbohydrate polymer : NEW Components: NAG
Carbohydrate polymer
1 bound ligand:
Ligand NAG 1 x NAG
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: AUSTRALIAN SYNCHROTRON BEAMLINE MX2
Spacegroup: P212121
Unit cell:
a: 111.647Å b: 157.251Å c: 168.306Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.238 0.236 0.278
Expression systems:
  • Spodoptera frugiperda
  • Escherichia coli K-12

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