› 6nra

Electron Microscopy
7.7Å resolution

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero hexadecamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-148234 (preferred)
Entry contents:
8 distinct polypeptide molecules
Macromolecules (8 distinct):
T-complex protein 1 subunit alpha Chains: A, I
Molecule details ›
Chains: A, I
Length: 534 amino acids
Theoretical weight: 58.06 KDa
Source organism: Homo sapiens
Expression system: Insect cell expression vector pTIE1
UniProt:
  • Canonical: P17987 (Residues: 1-534; Coverage: 96%)
Gene names: CCT1, CCTA, TCP1
Sequence domains: TCP-1/cpn60 chaperonin family
T-complex protein 1 subunit beta Chains: B, J
Molecule details ›
Chains: B, J
Length: 509 amino acids
Theoretical weight: 54.74 KDa
Source organism: Homo sapiens
Expression system: Insect cell expression vector pTIE1
UniProt:
  • Canonical: P78371 (Residues: 16-524; Coverage: 95%)
Gene names: 99D8.1, CCT2, CCTB
Sequence domains: TCP-1/cpn60 chaperonin family
T-complex protein 1 subunit gamma Chains: C, K
Molecule details ›
Chains: C, K
Length: 513 amino acids
Theoretical weight: 57.17 KDa
Source organism: Homo sapiens
Expression system: Insect cell expression vector pTIE1
UniProt:
  • Canonical: P49368 (Residues: 13-525; Coverage: 94%)
Gene names: CCT3, CCTG, TRIC5
Sequence domains: TCP-1/cpn60 chaperonin family
T-complex protein 1 subunit delta Chains: D, L
Molecule details ›
Chains: D, L
Length: 514 amino acids
Theoretical weight: 55.64 KDa
Source organism: Homo sapiens
Expression system: Insect cell expression vector pTIE1
UniProt:
  • Canonical: P50991 (Residues: 26-539; Coverage: 95%)
Gene names: CCT4, CCTD, SRB
Sequence domains: TCP-1/cpn60 chaperonin family
T-complex protein 1 subunit epsilon Chains: E, M
Molecule details ›
Chains: E, M
Length: 517 amino acids
Theoretical weight: 56.99 KDa
Source organism: Homo sapiens
Expression system: Insect cell expression vector pTIE1
UniProt:
  • Canonical: P48643 (Residues: 25-541; Coverage: 96%)
Gene names: CCT5, CCTE, KIAA0098
Sequence domains: TCP-1/cpn60 chaperonin family
T-complex protein 1 subunit zeta Chains: F, N
Molecule details ›
Chains: F, N
Length: 515 amino acids
Theoretical weight: 56.45 KDa
Source organism: Homo sapiens
Expression system: Insect cell expression vector pTIE1
UniProt:
  • Canonical: P40227 (Residues: 11-525; Coverage: 97%)
Gene names: CCT6, CCT6A, CCTZ
Sequence domains: TCP-1/cpn60 chaperonin family
T-complex protein 1 subunit eta Chains: G, O
Molecule details ›
Chains: G, O
Length: 514 amino acids
Theoretical weight: 56.37 KDa
Source organism: Homo sapiens
Expression system: Insect cell expression vector pTIE1
UniProt:
  • Canonical: Q99832 (Residues: 12-525; Coverage: 95%)
Gene names: CCT7, CCTH, NIP7-1
Sequence domains: TCP-1/cpn60 chaperonin family
T-complex protein 1 subunit theta Chains: H, P
Molecule details ›
Chains: H, P
Length: 514 amino acids
Theoretical weight: 56.1 KDa
Source organism: Homo sapiens
Expression system: Insect cell expression vector pTIE1
UniProt:
  • Canonical: P50990 (Residues: 14-527; Coverage: 94%)
Gene names: C21orf112, CCT8, CCTQ, KIAA0002
Sequence domains: TCP-1/cpn60 chaperonin family

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 7.7Å
Relevant EMDB volumes: EMD-0492
Expression system: Insect cell expression vector pTIE1

Quick links

Citations

10 review citations

The functions and regulation of heat shock proteins; key orchestrators of proteostasis and the heat shock response.
Lang et al. (2021)
9 more

4 mentions without citation

Molecular mechanisms of amyloid formation in living systems.
Sinnige T. (2022)
3 more