› 6nu2

Electron Microscopy
3.9Å resolution

Structural insights into unique features of the human mitochondrial ribosome recycling

Released:
DOI: 10.2210/pdb6nu2/pdb
PDB entry 6nu2 coloured by chain, front view.
PDB entry 6nu2 coloured by chain, side view.
PDB entry 6nu2 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural insights into unique features of the human mitochondrial ribosome recycling.
Koripella RK, Sharma MR, Risteff P, Keshavan P, Agrawal RK
Proc Natl Acad Sci U S A 116 8283-8288 (2019)
PMID: 30962385
Related structures: EMD-0514

Function and Biology Details

Reaction catalysed: 
N-substituted aminoacyl-tRNA + H(2)O = N-substituted amino acid + tRNA
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero 86-mer (preferred)
PDBe Complex ID:
PDB-CPX-127380 (preferred)
Entry contents:
82 distinct polypeptide molecules
4 distinct RNA molecules
Macromolecules (86 distinct):
Large ribosomal subunit protein uL2m Chain: D
Molecule details ›
Chain: D
Length: 236 amino acids
Theoretical weight: 26.26 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: Q5T653 (Residues: 61-296; Coverage: 77%)
Gene names: CGI-22, MRPL2
Sequence domains:
Large ribosomal subunit protein uL3m Chain: E
Molecule details ›
Chain: E
Length: 304 amino acids
Theoretical weight: 34.02 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P09001 (Residues: 45-348; Coverage: 87%)
Gene names: MRL3, MRPL3, RPML3
Sequence domains: Ribosomal protein L3
Large ribosomal subunit protein uL4m Chain: F
Molecule details ›
Chain: F
Length: 250 amino acids
Theoretical weight: 28.53 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: Q9BYD3 (Residues: 45-294; Coverage: 80%)
Gene names: CDABP0091, CGI-28, MRPL4
Sequence domains: Ribosomal protein L4/L1 family
Large ribosomal subunit protein bL9m Chain: H
Molecule details ›
Chain: H
Length: 95 amino acids
Theoretical weight: 11.13 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: Q9BYD2 (Residues: 53-147; Coverage: 36%)
Gene name: MRPL9
Sequence domains: Ribosomal protein L9, N-terminal domain
Large ribosomal subunit protein uL10m Chain: I
Molecule details ›
Chain: I
Length: 168 amino acids
Theoretical weight: 19.4 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: Q7Z7H8 (Residues: 30-197; Coverage: 64%)
Gene names: MRPL10, MRPL8, RPML8
Sequence domains: Ribosomal protein L10
Large ribosomal subunit protein uL11m Chain: J
Molecule details ›
Chain: J
Length: 140 amino acids
Theoretical weight: 15.09 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: Q9Y3B7 (Residues: 18-157; Coverage: 73%)
Gene names: CGI-113, MRPL11
Sequence domains:
Large ribosomal subunit protein uL13m Chain: K
Molecule details ›
Chain: K
Length: 177 amino acids
Theoretical weight: 20.59 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: Q9BYD1 (Residues: 2-178; Coverage: 99%)
Gene name: MRPL13
Sequence domains: Ribosomal protein L13
Large ribosomal subunit protein uL14m Chain: L
Molecule details ›
Chain: L
Length: 115 amino acids
Theoretical weight: 12.71 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: Q6P1L8 (Residues: 31-145; Coverage: 79%)
Gene names: MRPL14, MRPL32, RPML32
Sequence domains: Ribosomal protein L14p/L23e
Large ribosomal subunit protein uL15m Chain: M
Molecule details ›
Chain: M
Length: 287 amino acids
Theoretical weight: 32.7 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: Q9P015 (Residues: 10-296; Coverage: 97%)
Gene names: HSPC145, MRPL15
Sequence domains: Ribosomal proteins 50S-L15, 50S-L18e, 60S-L27A
Large ribosomal subunit protein uL16m Chain: N
Molecule details ›
Chain: N
Length: 205 amino acids
Theoretical weight: 23.54 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: Q9NX20 (Residues: 47-251; Coverage: 82%)
Gene names: MRPL16, PNAS-111
Sequence domains: Ribosomal protein L16p/L10e
Large ribosomal subunit protein bL17m Chain: O
Molecule details ›
Chain: O
Length: 152 amino acids
Theoretical weight: 17.76 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: Q9NRX2 (Residues: 9-160; Coverage: 87%)
Gene names: LIP2, MRPL17
Sequence domains: Ribosomal protein L17
Large ribosomal subunit protein uL18m Chain: P
Molecule details ›
Chain: P
Length: 138 amino acids
Theoretical weight: 15.99 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: Q9H0U6 (Residues: 43-180; Coverage: 77%)
Gene names: HSPC071, MRPL18
Sequence domains: Ribosomal L18 of archaea, bacteria, mitoch. and chloroplast
Large ribosomal subunit protein bL19m Chain: Q
Molecule details ›
Chain: Q
Length: 219 amino acids
Theoretical weight: 25.92 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P49406 (Residues: 74-292; Coverage: 75%)
Gene names: KIAA0104, MRPL15, MRPL19
Sequence domains: Ribosomal protein L19
Large ribosomal subunit protein bL20m Chain: R
Molecule details ›
Chain: R
Length: 140 amino acids
Theoretical weight: 16.39 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: Q9BYC9 (Residues: 10-149; Coverage: 94%)
Gene name: MRPL20
Sequence domains: Ribosomal protein L20
Large ribosomal subunit protein bL21m Chain: S
Molecule details ›
Chain: S
Length: 156 amino acids
Theoretical weight: 17.79 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: Q7Z2W9 (Residues: 49-204; Coverage: 76%)
Gene name: MRPL21
Sequence domains: Ribosomal prokaryotic L21 protein
Large ribosomal subunit protein uL22m Chain: T
Molecule details ›
Chain: T
Length: 166 amino acids
Theoretical weight: 19.47 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: Q9NWU5 (Residues: 41-206; Coverage: 81%)
Gene names: HSPC158, MRPL22, MRPL25, RPML25
Sequence domains: Ribosomal protein L22p/L17e
Large ribosomal subunit protein uL23m Chain: U
Molecule details ›
Chain: U
Length: 111 amino acids
Theoretical weight: 13.05 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: Q16540 (Residues: 2-112; Coverage: 73%)
Gene names: L23MRP, MRPL23, RPL23L
Sequence domains: Ribosomal protein L23
Large ribosomal subunit protein uL24m Chain: V
Molecule details ›
Chain: V
Length: 202 amino acids
Theoretical weight: 23.5 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: Q96A35 (Residues: 15-216; Coverage: 94%)
Gene name: MRPL24
Sequence domains:
Large ribosomal subunit protein bL27m Chain: W
Molecule details ›
Chain: W
Length: 115 amino acids
Theoretical weight: 12.7 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: Q9P0M9 (Residues: 34-148; Coverage: 78%)
Gene names: HSPC250, MRPL27
Sequence domains: Ribosomal L27 protein
Large ribosomal subunit protein bL28m Chain: X
Molecule details ›
Chain: X
Length: 243 amino acids
Theoretical weight: 28.82 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: Q13084 (Residues: 2-244; Coverage: 95%)
Gene names: MAAT1, MRPL28
Sequence domains: Ribosomal L28 family
Large ribosomal subunit protein uL29m Chain: Y
Molecule details ›
Chain: Y
Length: 176 amino acids
Theoretical weight: 21.51 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: Q9HD33 (Residues: 63-238; Coverage: 70%)
Gene names: CGI-204, MRPL47, NCM1
Sequence domains: Mitochondrial 39-S ribosomal protein L47 (MRP-L47)
Large ribosomal subunit protein uL30m Chain: Z
Molecule details ›
Chain: Z
Length: 120 amino acids
Theoretical weight: 13.91 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: Q8TCC3 (Residues: 35-154; Coverage: 75%)
Gene names: HSPC249, MRPL28, MRPL30, RPML28
Sequence domains: Ribosomal protein L30p/L7e
Large ribosomal subunit protein bL32m Chain: 0
Molecule details ›
Chain: 0
Length: 108 amino acids
Theoretical weight: 12.61 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: Q9BYC8 (Residues: 79-186; Coverage: 57%)
Gene names: HSPC283, MRPL32
Sequence domains: Ribosomal L32p protein family
Large ribosomal subunit protein bL33m Chain: 1
Molecule details ›
Chain: 1
Length: 52 amino acids
Theoretical weight: 6.19 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: O75394 (Residues: 14-65; Coverage: 80%)
Gene names: C2orf1, MRPL33
Sequence domains: Ribosomal protein L33
Large ribosomal subunit protein bL34m Chain: 2
Molecule details ›
Chain: 2
Length: 46 amino acids
Theoretical weight: 5.37 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: Q9BQ48 (Residues: 47-92; Coverage: 50%)
Gene name: MRPL34
Sequence domains: Ribosomal protein L34
Large ribosomal subunit protein bL35m Chain: 3
Molecule details ›
Chain: 3
Length: 95 amino acids
Theoretical weight: 11.79 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: Q9NZE8 (Residues: 94-188; Coverage: 51%)
Gene names: BM-007, MRPL35
Sequence domains: Ribosomal protein L35
Large ribosomal subunit protein bL36m Chain: 4
Molecule details ›
Chain: 4
Length: 36 amino acids
Theoretical weight: 4.62 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: Q9P0J6 (Residues: 67-102; Coverage: 35%)
Gene names: BRIP1, MRPL36
Sequence domains: Ribosomal protein L36
Large ribosomal subunit protein mL37 Chain: 5
Molecule details ›
Chain: 5
Length: 392 amino acids
Theoretical weight: 45.3 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: Q9BZE1 (Residues: 31-422; Coverage: 93%)
Gene names: HSPC235, MRPL2, MRPL37, RPML2
Sequence domains: Mitochondrial 28S ribosomal protein S30 (PDCD9)
Large ribosomal subunit protein mL38 Chain: 6
Molecule details ›
Chain: 6
Length: 354 amino acids
Theoretical weight: 41.69 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: Q96DV4 (Residues: 27-380; Coverage: 93%)
Gene names: HSPC262, MRPL38
Sequence domains: Phosphatidylethanolamine-binding protein
Large ribosomal subunit protein mL39 Chain: 7
Molecule details ›
Chain: 7
Length: 287 amino acids
Theoretical weight: 33.29 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: Q9NYK5 (Residues: 36-322; Coverage: 85%)
Gene names: C21orf92, MRPL39, MRPL5, MSTP003, PRED22, RPML5
Large ribosomal subunit protein mL40 Chain: 8
Molecule details ›
Chain: 8
Length: 99 amino acids
Theoretical weight: 11.88 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: Q9NQ50 (Residues: 83-181; Coverage: 48%)
Gene names: MRPL40, NLVCF, URIM
Sequence domains: Mitochondrial ribosomal protein L28
Large ribosomal subunit protein mL41 Chain: 9
Molecule details ›
Chain: 9
Length: 123 amino acids
Theoretical weight: 14.03 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: Q8IXM3 (Residues: 15-137; Coverage: 90%)
Gene names: BMRP, MRPL27, MRPL41, PIG3, RPML27
Sequence domains: Mitochondrial ribosomal protein L27
Large ribosomal subunit protein mL42 Chain: a
Molecule details ›
Chain: a
Length: 108 amino acids
Theoretical weight: 12.87 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: Q9Y6G3 (Residues: 35-142; Coverage: 76%)
Gene names: HSPC204, MRPL31, MRPL42, MRPS32, PTD007, RPML31
Sequence domains: Mitochondrial 28S ribosomal protein S32
Large ribosomal subunit protein mL43 Chain: b
Molecule details ›
Chain: b
Length: 148 amino acids
Theoretical weight: 16.74 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: Q8N983 (Residues: 2-149; Coverage: 69%)
Gene name: MRPL43
Sequence domains: Mitochondrial ribosomal protein L51 / S25 / CI-B8 domain
Large ribosomal subunit protein mL44 Chain: c
Molecule details ›
Chain: c
Length: 286 amino acids
Theoretical weight: 32.69 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: Q9H9J2 (Residues: 31-316; Coverage: 86%)
Gene name: MRPL44
Large ribosomal subunit protein mL45 Chain: d
Molecule details ›
Chain: d
Length: 171 amino acids
Theoretical weight: 20.09 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: Q9BRJ2 (Residues: 117-287; Coverage: 56%)
Gene name: MRPL45
Sequence domains: Tim44-like domain
Large ribosomal subunit protein mL46 Chain: e
Molecule details ›
Chain: e
Length: 237 amino acids
Theoretical weight: 27.36 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: Q9H2W6 (Residues: 43-279; Coverage: 85%)
Gene names: C15orf4, LIECG2, MRPL46
Sequence domains: 39S mitochondrial ribosomal protein L46
Large ribosomal subunit protein mL48 Chain: f
Molecule details ›
Chain: f
Length: 146 amino acids
Theoretical weight: 16.48 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: Q96GC5 (Residues: 48-193; Coverage: 69%)
Gene names: CGI-118, HSPC290, MRPL48
Sequence domains: Ribosomal protein S10p/S20e
Large ribosomal subunit protein mL49 Chain: g
Molecule details ›
Chain: g
Length: 129 amino acids
Theoretical weight: 15.09 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: Q13405 (Residues: 38-166; Coverage: 78%)
Gene names: C11orf4, MRPL49, NOF1, OK/SW-cl.67
Sequence domains: Mitochondrial large subunit ribosomal protein (Img2)
Large ribosomal subunit protein mL50 Chain: h
Molecule details ›
Chain: h
Length: 103 amino acids
Theoretical weight: 11.96 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: Q8N5N7 (Residues: 56-158; Coverage: 65%)
Gene name: MRPL50
Sequence domains: Ribosomal subunit 39S
Large ribosomal subunit protein mL51 Chain: i
Molecule details ›
Chain: i
Length: 97 amino acids
Theoretical weight: 11.74 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: Q4U2R6 (Residues: 32-128; Coverage: 76%)
Gene names: CDA09, HSPC241, MRP64, MRPL51
Sequence domains: Mitochondrial ribosomal subunit
Large ribosomal subunit protein mL52 Chain: j
Molecule details ›
Chain: j
Length: 85 amino acids
Theoretical weight: 9.73 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: Q86TS9 (Residues: 24-108; Coverage: 69%)
Gene name: MRPL52
Sequence domains: Mitoribosomal protein mL52
Large ribosomal subunit protein mL53 Chain: k
Molecule details ›
Chain: k
Length: 84 amino acids
Theoretical weight: 9.39 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: Q96EL3 (Residues: 13-96; Coverage: 75%)
Gene name: MRPL53
Sequence domains: 39S ribosomal protein L53/MRP-L53
Large ribosomal subunit protein mL54 Chain: l
Molecule details ›
Chain: l
Length: 23 amino acids
Theoretical weight: 3.14 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: Q6P161 (Residues: 114-136; Coverage: 17%)
Gene name: MRPL54
Large ribosomal subunit protein mL55 Chain: m
Molecule details ›
Chain: m
Length: 45 amino acids
Theoretical weight: 5.32 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: Q7Z7F7 (Residues: 34-78; Coverage: 35%)
Gene names: MRPL55, UNQ5835/PRO19675
Sequence domains: Mitochondrial ribosomal protein L55
Large ribosomal subunit protein mL63 Chain: o
Molecule details ›
Chain: o
Length: 94 amino acids
Theoretical weight: 11.32 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: Q9BQC6 (Residues: 9-102; Coverage: 92%)
Gene names: MRP63, MRPL57
Sequence domains: Mitochondrial ribosome protein 63
Large ribosomal subunit protein mL62 Chain: p
Molecule details ›
Chain: p
Length: 156 amino acids
Theoretical weight: 18.02 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: Q14197 (Residues: 38-193; Coverage: 76%)
Gene names: DS1, ICT1, MRPL58
Sequence domains: RF-1 domain
Large ribosomal subunit protein mL64 Chain: q
Molecule details ›
Chain: q
Length: 128 amino acids
Theoretical weight: 15.3 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: Q8TAE8 (Residues: 25-152; Coverage: 58%)
Gene names: GADD45GIP1, MRPL59, PLINP1, PRG6
Sequence domains: Growth arrest and DNA-damage-inducible proteins-interacting protein 1
Large ribosomal subunit protein mL66 Chain: r
Molecule details ›
Chain: r
Length: 162 amino acids
Theoretical weight: 18.81 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: Q9NVS2 (Residues: 35-196; Coverage: 83%)
Gene name: MRPS18A
Sequence domains: Ribosomal protein S18
Large ribosomal subunit protein mL65 Chain: s
Molecule details ›
Chain: s
Length: 390 amino acids
Theoretical weight: 45.2 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: Q9NP92 (Residues: 41-430; Coverage: 89%)
Gene names: BM-047, MRPS30, PDCD9
Sequence domains: Mitochondrial 28S ribosomal protein S30 (PDCD9)
Unknown protein/protein extension Chain: t
Molecule details ›
Chain: t
Length: 28 amino acids
Theoretical weight: 2.4 KDa
Source organism: Homo sapiens
Ribosome-recycling factor, mitochondrial Chain: z
Molecule details ›
Chain: z
Length: 204 amino acids
Theoretical weight: 22.59 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: Q96E11 (Residues: 59-262; Coverage: 78%)
Gene name: MRRF
Sequence domains: Ribosome recycling factor
Small ribosomal subunit protein uS2m Chain: AB
Molecule details ›
Chain: AB
Length: 217 amino acids
Theoretical weight: 25.13 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: Q9Y399 (Residues: 58-274; Coverage: 73%)
Gene names: CGI-91, MRPS2
Sequence domains: Ribosomal protein S2
Small ribosomal subunit protein uS3m Chain: AC
Molecule details ›
Chain: AC
Length: 132 amino acids
Theoretical weight: 15.33 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: Q96EL2 (Residues: 36-167; Coverage: 79%)
Gene names: HSPC335, MRPS24
Sequence domains: Mitochondrial ribosome subunit S24
Small ribosomal subunit protein uS5m Chain: AD
Molecule details ›
Chain: AD
Length: 343 amino acids
Theoretical weight: 38.92 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P82675 (Residues: 88-430; Coverage: 80%)
Gene name: MRPS5
Sequence domains:
Small ribosomal subunit protein bS6m Chain: AE
Molecule details ›
Chain: AE
Length: 122 amino acids
Theoretical weight: 13.86 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P82932 (Residues: 2-123; Coverage: 98%)
Gene names: C21orf101, MRPS6, RPMS6
Sequence domains: Ribosomal protein S6
Small ribosomal subunit protein uS7m Chain: AF
Molecule details ›
Chain: AF
Length: 208 amino acids
Theoretical weight: 24.57 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: Q9Y2R9 (Residues: 35-242; Coverage: 86%)
Gene name: MRPS7
Sequence domains: Ribosomal protein S7p/S5e
Small ribosomal subunit protein uS9m Chain: AG
Molecule details ›
Chain: AG
Length: 326 amino acids
Theoretical weight: 38.07 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P82933 (Residues: 71-396; Coverage: 82%)
Gene names: MRPS9, RPMS9
Sequence domains: Ribosomal protein S9/S16
Small ribosomal subunit protein uS10m Chain: AH
Molecule details ›
Chain: AH
Length: 122 amino acids
Theoretical weight: 14.21 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P82664 (Residues: 61-182; Coverage: 61%)
Gene names: MRPS10, MSTP040
Sequence domains: Ribosomal protein S10p/S20e
Small ribosomal subunit protein uS11m Chain: AI
Molecule details ›
Chain: AI
Length: 136 amino acids
Theoretical weight: 14.41 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P82912 (Residues: 59-194; Coverage: 70%)
Gene names: HCC2, MRPS11, RPMS11
Sequence domains: Ribosomal protein S11
Small ribosomal subunit protein uS12m Chain: AJ
Molecule details ›
Chain: AJ
Length: 108 amino acids
Theoretical weight: 12.01 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: O15235 (Residues: 31-138; Coverage: 78%)
Gene names: MRPS12, RPMS12, RPSM12
Sequence domains: Ribosomal protein S12/S23
Small ribosomal subunit protein uS14m Chain: AK
Molecule details ›
Chain: AK
Length: 101 amino acids
Theoretical weight: 12.28 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: O60783 (Residues: 28-128; Coverage: 79%)
Gene name: MRPS14
Sequence domains: Ribosomal protein S14p/S29e
Small ribosomal subunit protein uS15m Chain: AL
Molecule details ›
Chain: AL
Length: 164 amino acids
Theoretical weight: 19.72 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P82914 (Residues: 66-229; Coverage: 64%)
Gene names: DC37, MRPS15, RPMS15
Sequence domains: Ribosomal protein S15
Small ribosomal subunit protein bS16m Chain: AM
Molecule details ›
Chain: AM
Length: 116 amino acids
Theoretical weight: 13.12 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: Q9Y3D3 (Residues: 10-125; Coverage: 85%)
Gene names: CGI-132, MRPS16, RPMS16
Sequence domains: Ribosomal protein S16
Small ribosomal subunit protein uS17m Chain: AN
Molecule details ›
Chain: AN
Length: 107 amino acids
Theoretical weight: 12.03 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: Q9Y2R5 (Residues: 5-111; Coverage: 82%)
Gene names: HSPC011, MRPS17, RPMS17
Sequence domains: Ribosomal protein S17
Small ribosomal subunit protein mS40 Chain: AO
Molecule details ›
Chain: AO
Length: 185 amino acids
Theoretical weight: 21.66 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: Q9Y676 (Residues: 52-236; Coverage: 72%)
Gene names: C6orf14, HSPC183, MRPS18B, PTD017
Sequence domains: Ribosomal protein S18
Small ribosomal subunit protein bS18m Chain: AP
Molecule details ›
Chain: AP
Length: 96 amino acids
Theoretical weight: 11.1 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: Q9Y3D5 (Residues: 47-142; Coverage: 68%)
Gene names: CGI-134, MRPS18C
Sequence domains: Ribosomal protein S18
Small ribosomal subunit protein bS21m Chain: AQ
Molecule details ›
Chain: AQ
Length: 86 amino acids
Theoretical weight: 10.58 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P82921 (Residues: 2-87; Coverage: 99%)
Gene names: MDS016, MRPS21, RPMS21
Sequence domains: Ribosomal protein S21
Small ribosomal subunit protein mS22 Chain: AR
Molecule details ›
Chain: AR
Length: 242 amino acids
Theoretical weight: 28.56 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P82650 (Residues: 67-308; Coverage: 67%)
Gene names: C3orf5, GK002, MRPS22, RPMS22
Sequence domains: Mitochondrial 28S ribosomal protein S22
Small ribosomal subunit protein mS23 Chain: AS
Molecule details ›
Chain: AS
Length: 126 amino acids
Theoretical weight: 14.72 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: Q9Y3D9 (Residues: 2-127; Coverage: 66%)
Gene names: CGI-138, HSPC329, MRPS23
Sequence domains: Mitochondrial ribosomal protein S23
Small ribosomal subunit protein mS25 Chain: AT
Molecule details ›
Chain: AT
Length: 162 amino acids
Theoretical weight: 19 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P82663 (Residues: 2-163; Coverage: 94%)
Gene names: MRPS25, RPMS25
Sequence domains: Mitochondrial ribosomal protein L51 / S25 / CI-B8 domain
Small ribosomal subunit protein mS26 Chain: AU
Molecule details ›
Chain: AU
Length: 173 amino acids
Theoretical weight: 20.8 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: Q9BYN8 (Residues: 27-199; Coverage: 84%)
Gene names: C20orf193, MRPS26, RPMS13
Sequence domains: Mitochondrial ribosome subunit S26
Small ribosomal subunit protein mS27 Chain: AV
Molecule details ›
Chain: AV
Length: 365 amino acids
Theoretical weight: 42.36 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: Q92552 (Residues: 36-400; Coverage: 88%)
Gene names: KIAA0264, MRPS27
Sequence domains: Mitochondrial 28S ribosomal protein S27
Small ribosomal subunit protein bS1m Chain: AW
Molecule details ›
Chain: AW
Length: 97 amino acids
Theoretical weight: 10.93 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: Q9Y2Q9 (Residues: 77-173; Coverage: 52%)
Gene names: HSPC007, MRPS28, MRPS35
Sequence domains: Mitochondrial ribosomal protein MRP-S35
Small ribosomal subunit protein mS29 Chain: AX
Molecule details ›
Chain: AX
Length: 348 amino acids
Theoretical weight: 39.99 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P51398 (Residues: 51-398; Coverage: 87%)
Gene names: DAP3, MRPS29
Sequence domains: Mitochondrial ribosomal death-associated protein 3
Small ribosomal subunit protein mS31 Chain: AY
Molecule details ›
Chain: AY
Length: 108 amino acids
Theoretical weight: 12.9 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: Q92665 (Residues: 276-383; Coverage: 27%)
Gene names: IMOGN38, MRPS31
Sequence domains: Mitochondrial 28S ribosomal protein S31
Small ribosomal subunit protein mS33 Chain: AZ
Molecule details ›
Chain: AZ
Length: 87 amino acids
Theoretical weight: 10.54 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: Q9Y291 (Residues: 5-91; Coverage: 82%)
Gene names: CGI-139, MRPS33, PTD003
Sequence domains: Mitochondrial ribosomal subunit S27
Small ribosomal subunit protein mS34 Chain: A0
Molecule details ›
Chain: A0
Length: 208 amino acids
Theoretical weight: 24.59 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P82930 (Residues: 6-213; Coverage: 95%)
Gene name: MRPS34
Sequence domains: Mitochondrial 28S ribosomal protein S34
Small ribosomal subunit protein mS35 Chain: A1
Molecule details ›
Chain: A1
Length: 272 amino acids
Theoretical weight: 31.36 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P82673 (Residues: 52-323; Coverage: 84%)
Gene names: HDCMD11P, MDS023, MRPS28, MRPS35, PSEC0213
Sequence domains: Mitochondrial ribosomal subunit protein
Small ribosomal subunit protein mS37 Chain: A2
Molecule details ›
Chain: A2
Length: 116 amino acids
Theoretical weight: 13.28 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: Q96BP2 (Residues: 2-117; Coverage: 98%)
Gene names: C10orf34, CHCHD1, MRPS37
Sequence domains: CHCH domain
Small ribosomal subunit protein mS38 Chain: A3
Molecule details ›
Chain: A3
Length: 69 amino acids
Theoretical weight: 8.72 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: Q9NWT8 (Residues: 128-196; Coverage: 35%)
Gene names: AIP, AKIP, AURKAIP1, MRPS38
Sequence domains: Mitochondrial mRNA-processing protein COX24, C-terminal
Small ribosomal subunit protein mS39 Chain: A4
Molecule details ›
Chain: A4
Length: 474 amino acids
Theoretical weight: 50.1 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: Q96EY7 (Residues: 56-639; Coverage: 69%)
Gene names: MRPS39, PTCD3, TRG15
Sequence domains: Pentatricopeptide repeat domain
16S ribosomal RNA Chain: A
Molecule details ›
Chain: A
Length: 1472 nucleotides
Theoretical weight: 472.44 KDa
Sequence domains: Bacterial large subunit ribosomal RNA
mt-tRNAVal Chain: B
Molecule details ›
Chain: B
Length: 56 nucleotides
Theoretical weight: 17.96 KDa
E-site tRNA Chain: u
Molecule details ›
Chain: u
Length: 2 nucleotides
Theoretical weight: 589 Da
12S rRNA Chain: AA
Molecule details ›
Chain: AA
Length: 923 nucleotides
Theoretical weight: 296.32 KDa
Sequence domains: Bacterial small subunit ribosomal RNA

Ligands and Environments

2 bound ligands:
Ligand MG 127 x MG
Ligand ZN 7 x ZN
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.9Å
Relevant EMDB volumes: EMD-0514

Quick links

Citations

3 review citations

The Diseased Mitoribosome.
Ferrari et al. (2021)
2 more

6 mentions without citation

Maintaining mitochondrial ribosome function: The role of ribosome rescue and recycling factors.
Nadler et al. (2022)
5 more