Function and Biology Details
Reaction catalysed:
[a protein]-serine/threonine phosphate + H(2)O = [a protein]-serine/threonine + phosphate
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
- EF-hand domain
- Serine/threonine-specific protein phosphatase/bis(5-nucleosyl)-tetraphosphatase
- EF-Hand 1, calcium-binding site
- Sodium/hydrogen exchanger 1-like
- Metallo-dependent phosphatase-like
- Calcineurin B protein
- EF-hand domain pair
- Calcineurin-like phosphoesterase domain, ApaH type
2 more domains
Structure analysis Details
Assembly composition:
hetero trimer (preferred)
PDBe Complex ID:
PDB-CPX-148673 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
Protein phosphatase 3 catalytic subunit alpha
Molecule details ›
Chain: A
Length: 372 amino acids
Theoretical weight: 42.7 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
Sequence domains: Calcineurin-like phosphoesterase
Length: 372 amino acids
Theoretical weight: 42.7 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
- Canonical:
Q08209 (Residues: 1-370; Coverage: 71%)
Sequence domains: Calcineurin-like phosphoesterase
Calcineurin subunit B type 1
Molecule details ›
Chain: B
Length: 156 amino acids
Theoretical weight: 17.76 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
Sequence domains: EF-hand domain pair
Length: 156 amino acids
Theoretical weight: 17.76 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
- Canonical: P63098 (Residues: 16-170; Coverage: 91%)
Sequence domains: EF-hand domain pair
Sodium/hydrogen exchanger 1
Molecule details ›
Chain: C
Length: 48 amino acids
Theoretical weight: 5.27 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
Length: 48 amino acids
Theoretical weight: 5.27 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
- Canonical: P19634 (Residues: 679-723; Coverage: 6%)
