Function and Biology Details
Reaction catalysed:
(1a) NAD(+) = cyclic ADP-ribose + nicotinamide
Biochemical function:
Biological process:
Cellular component:
- not assigned
Structure analysis Details
Assembly composition:
homo octamer (preferred)
Assembly name:
NAD(+) hydrolase SARM1 (preferred)
PDBe Complex ID:
PDB-CPX-180347 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
NAD(+) hydrolase SARM1
Molecule details ›
Chains: A, B, C, D, E, F, G, H
Length: 177 amino acids
Theoretical weight: 20.3 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
Sequence domains: SAM domain (Sterile alpha motif)
Length: 177 amino acids
Theoretical weight: 20.3 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
- Canonical:
Q6SZW1 (Residues: 409-561; Coverage: 21%)
Sequence domains: SAM domain (Sterile alpha motif)
Ligands and Environments
No bound ligands
No modified residues
Experiments and Validation Details
X-ray source:
AUSTRALIAN SYNCHROTRON BEAMLINE MX2
Expression system: Escherichia coli
