6o3o

X-ray diffraction
2.8Å resolution

Structure of human DNAM-1 (CD226) bound to nectin-like protein-5 (necl-5)

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero tetramer (preferred)
PDBe Complex ID:
PDB-CPX-147251 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (5 distinct):
CD226 antigen Chains: A, B
Molecule details ›
Chains: A, B
Length: 243 amino acids
Theoretical weight: 27.69 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q15762 (Residues: 19-250; Coverage: 73%)
Gene names: CD226, DNAM1
Sequence domains: Immunoglobulin V-set domain
Poliovirus receptor Chains: C, D
Molecule details ›
Chains: C, D
Length: 317 amino acids
Theoretical weight: 34.7 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:
  • Canonical: P15151 (Residues: 28-334; Coverage: 77%)
Gene names: PVR, PVS
Sequence domains:

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG, BMA, FUC
Carbohydrate polymer : NEW Components: NAG, BMA, FUC, MAN
Carbohydrate polymer : NEW Components: NAG
2 bound ligands:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: AUSTRALIAN SYNCHROTRON BEAMLINE MX2
Spacegroup: C2221
Unit cell:
a: 129.337Å b: 182.269Å c: 146.594Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.209 0.208 0.231
Expression systems:
  • Homo sapiens
  • Trichoplusia ni