› 6o4o

X-ray diffraction
1.62Å resolution

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-149065 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Interleukin-11 Chain: A
Molecule details ›
Chain: A
Length: 169 amino acids
Theoretical weight: 18.27 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: P20809 (Residues: 32-199; Coverage: 94%)
Gene name: IL11
Sequence domains: Interleukin 11

Ligands and Environments

2 bound ligands:
Ligand SO4 1 x SO4
Ligand CL 1 x CL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: AUSTRALIAN SYNCHROTRON BEAMLINE MX2
Spacegroup: P21212
Unit cell:
a: 39.02Å b: 133.762Å c: 27.183Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.178 0.176 0.208
Expression system: Escherichia coli BL21

Quick links

Citations

4 review citations

The Role of gp130 Cytokines in Tuberculosis.
Ritter et al. (2020)
3 more

7 mentions without citation

Structural Understanding of Interleukin 6 Family Cytokine Signaling and Targeted Therapies: Focus on Interleukin 11.
Metcalfe et al. (2020)
6 more