› 6o9h

X-ray diffraction
2.1Å resolution

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-211991 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
Heavy chain Chains: A, H
Molecule details ›
Chains: A, H
Length: 225 amino acids
Theoretical weight: 24.09 KDa
Source organism: Homo sapiens
Expression system: Cricetulus griseus
Light chain Chains: B, L
Molecule details ›
Chains: B, L
Length: 220 amino acids
Theoretical weight: 24.22 KDa
Source organism: Homo sapiens
Expression system: Cricetulus griseus
Gastric inhibitory polypeptide receptor Chains: C, D
Molecule details ›
Chains: C, D
Length: 137 amino acids
Theoretical weight: 15.67 KDa
Source organism: Mus musculus
Expression system: Escherichia coli
UniProt:
  • Canonical: Q0P543 (Residues: 19-134; Coverage: 26%)
Gene name: Gipr
Sequence domains: Hormone receptor domain

Ligands and Environments

1 bound ligand:
Ligand NA 2 x NA
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 5.0.2
Spacegroup: P21
Unit cell:
a: 74.078Å b: 48.974Å c: 150.908Å
α: 90° β: 101.08° γ: 90°
R-values:
R R work R free
0.205 0.203 0.248
Expression systems:
  • Cricetulus griseus
  • Escherichia coli

Quick links

Citations

2 review citations

Targeting the GIPR for obesity: To agonize or antagonize? Potential mechanisms.
Campbell JE. (2021)
1 more

1 mention without citation

Molecular mechanism of an antagonistic antibody against glucose-dependent insulinotropic polypeptide receptor.
Min et al. (2020)