› 6o9i

X-ray diffraction
2.6Å resolution

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero pentamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-232131 (preferred)
Entry contents:
5 distinct polypeptide molecules
Macromolecules (5 distinct):
Fab1 heavy chain Chain: A
Molecule details ›
Chain: A
Length: 225 amino acids
Theoretical weight: 24.09 KDa
Source organism: Homo sapiens
Expression system: Cricetulus griseus
Fab1 light chain Chain: B
Molecule details ›
Chain: B
Length: 220 amino acids
Theoretical weight: 24.22 KDa
Source organism: Homo sapiens
Expression system: Cricetulus griseus
Gastric inhibitory polypeptide receptor Chain: C
Molecule details ›
Chain: C
Length: 137 amino acids
Theoretical weight: 15.67 KDa
Source organism: Mus musculus
Expression system: Escherichia coli
UniProt:
  • Canonical: Q0P543 (Residues: 19-134; Coverage: 26%)
Gene name: Gipr
Sequence domains: Hormone receptor domain
Fab 2 heavy chain Chain: D
Molecule details ›
Chain: D
Length: 226 amino acids
Theoretical weight: 24.47 KDa
Source organism: Homo sapiens
Expression system: Cricetulus griseus
Fab2 light chain Chain: E
Molecule details ›
Chain: E
Length: 220 amino acids
Theoretical weight: 24.17 KDa
Source organism: Homo sapiens
Expression system: Cricetulus griseus

Ligands and Environments

1 bound ligand:
Ligand EDO 5 x EDO
1 modified residue:
Ligand PCA 1 x PCA

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 5.0.2
Spacegroup: P1
Unit cell:
a: 41.43Å b: 43.68Å c: 133.82Å
α: 87.86° β: 88.38° γ: 81.17°
R-values:
R R work R free
0.219 0.216 0.266
Expression systems:
  • Cricetulus griseus
  • Escherichia coli

Quick links

Citations

2 review citations

Targeting the GIPR for obesity: To agonize or antagonize? Potential mechanisms.
Campbell JE. (2021)
1 more

1 mention without citation

Molecular mechanism of an antagonistic antibody against glucose-dependent insulinotropic polypeptide receptor.
Min et al. (2020)