› 6oif

Electron Microscopy
4.4Å resolution

Cryo-EM structure of human TorsinA filament

Released:
DOI: 10.2210/pdb6oif/pdb
PDB entry 6oif coloured by chain, front view.
PDB entry 6oif coloured by chain, side view.
PDB entry 6oif coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
The AAA + ATPase TorsinA polymerizes into hollow helical tubes with 8.5 subunits per turn.
Demircioglu FE, Zheng W, McQuown AJ, Maier NK, Watson N, Cheeseman IM, Denic V, Egelman EH, Schwartz TU
Nat Commun 10 3262 (2019)
PMID: 31332180
Related structures: EMD-20076

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo 25-mer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-127049 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Torsin-1A Chains: A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P, Q, R, S, T, U, V, W, X, Y
Molecule details ›
Chains: A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P, Q, R, S, T, U, V, W, X, Y
Length: 282 amino acids
Theoretical weight: 32.59 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: O14656 (Residues: 51-332; Coverage: 90%)
Gene names: DQ2, DYT1, TA, TOR1A, TORA
Sequence domains:

Ligands and Environments

1 bound ligand:
Ligand ATP 25 x ATP
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 4.4Å
Relevant EMDB volumes: EMD-20076
Expression system: Escherichia coli

Quick links

Citations

4 review citations

AAA+ ATPases: structural insertions under the magnifying glass.
Jessop et al. (2021)
3 more

2 mentions without citation

Resolving the TorsinA Oligomerization Conundrum: The Glycan Hypothesis.
Fercher et al. (2020)
1 more