› 6okd

X-ray diffraction
1.85Å resolution

Crystal Structure of human transferrin receptor in complex with a cystine-dense peptide

Released:
DOI: 10.2210/pdb6okd/pdb
PDB entry 6okd coloured by chain, front view.
PDB entry 6okd coloured by chain, side view.
PDB entry 6okd coloured by chain, top view.
Source organisms:
Primary publication:
A TfR-Binding Cystine-Dense Peptide Promotes Blood-Brain Barrier Penetration of Bioactive Molecules.
Crook ZR, Girard E, Sevilla GP, Merrill M, Friend D, Rupert PB, Pakiam F, Nguyen E, Yin C, Ruff RO, Hopping G, Strand AD, Finton KAK, Coxon M, Mhyre AJ, Strong RK, Olson JM
J Mol Biol 432 3989-4009 (2020)
PMID: 32304700

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-136211 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Transferrin receptor protein 1, serum form Chains: A, B
Molecule details ›
Chains: A, B
Length: 670 amino acids
Theoretical weight: 75.05 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P02786 (Residues: 121-760; Coverage: 84%)
Gene name: TFRC
Sequence domains:
transferrin receptor binding cystine-dense peptide Chains: C, D
Molecule details ›
Chains: C, D
Length: 51 amino acids
Theoretical weight: 5.96 KDa
Source organism: Monosiga brevicollis
Expression system: Homo sapiens

Ligands and Environments

3 bound ligands:
Ligand MES 2 x MES
Ligand GOL 10 x GOL
Ligand NAG 4 x NAG
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 5.0.1
Spacegroup: C2
Unit cell:
a: 102.601Å b: 145.5Å c: 133.494Å
α: 90° β: 90.02° γ: 90°
R-values:
R R work R free
0.164 0.163 0.187
Expression system: Homo sapiens

Quick links

Citations

7 review citations

A Historical Review of Brain Drug Delivery.
Pardridge WM. (2022)
6 more

4 mentions without citation

Single-Molecule Imaging of Membrane Proteins on Vascular Endothelial Cells.
Park et al. (2023)
3 more