› 6okm

X-ray diffraction
2.1Å resolution

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-211245 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
Fab 3C8 Heavy Chain Chain: H
Molecule details ›
Chain: H
Length: 222 amino acids
Theoretical weight: 23.61 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
Fab 3C8 light chain Chain: L
Molecule details ›
Chain: L
Length: 214 amino acids
Theoretical weight: 23.5 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
Tumor necrosis factor receptor superfamily member 4 Chain: R
Molecule details ›
Chain: R
Length: 163 amino acids
Theoretical weight: 17.7 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P43489 (Residues: 29-170; Coverage: 57%)
Gene names: TNFRSF4, TXGP1L
Sequence domains: TNFR/NGFR cysteine-rich region

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 5.0.2
Spacegroup: P4122
Unit cell:
a: 117.006Å b: 117.006Å c: 118.907Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.212 0.211 0.238
Expression systems:
  • Escherichia coli
  • Spodoptera frugiperda

Quick links

Citations

8 review citations

Avidity in antibody effector functions and biotherapeutic drug design.
Oostindie et al. (2022)
7 more

2 mentions without citation

Structural Basis of a Novel Agonistic Anti-OX40 Antibody.
Zhang et al. (2022)
1 more