› 6p2u

X-ray diffraction
2Å resolution

Structure of Mortalin-NBD with N6-propargyladenosine-5'-diphosphate

Released:
DOI: 10.2210/pdb6p2u/pdb
PDB entry 6p2u coloured by chain, front view.
PDB entry 6p2u coloured by chain, side view.
PDB entry 6p2u coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
2- and N6-functionalized adenosine-5'-diphosphate analogs for the inhibition of mortalin.
Moseng MA, Nix JC, Page RC
FEBS Lett 593 2030-2039 (2019)
PMID: 31177526

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-153699 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Stress-70 protein, mitochondrial Chain: A
Molecule details ›
Chain: A
Length: 385 amino acids
Theoretical weight: 41.42 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P38646 (Residues: 52-431; Coverage: 56%)
Gene names: GRP75, HSPA9, HSPA9B, mt-HSP70
Sequence domains: Hsp70 protein

Ligands and Environments

3 bound ligands:
Ligand NO7 1 x NO7
Ligand PO4 1 x PO4
Ligand MG 1 x MG
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 4.2.2
Spacegroup: P212121
Unit cell:
a: 51.04Å b: 68.25Å c: 121.22Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.217 0.216 0.238
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

1 review citation

Abrogating the Interaction Between p53 and Mortalin (Grp75/HSPA9/mtHsp70) for Cancer Therapy: The Story so far.
Elwakeel A. (2022)
1 other article

2 mentions without citation

Arsenic trioxide targets Hsp60, triggering degradation of p53 and survivin.
Hu et al. (2021)
1 more