› 6p46

Electron Microscopy
3.5Å resolution

Cryo-EM structure of TMEM16F in digitonin with calcium bound

Released:
DOI: 10.2210/pdb6p46/pdb
PDB entry 6p46 coloured by chain, front view.
PDB entry 6p46 coloured by chain, side view.
PDB entry 6p46 coloured by chain, top view.
Source organism: Mus musculus
Primary publication:
Cryo-EM Studies of TMEM16F Calcium-Activated Ion Channel Suggest Features Important for Lipid Scrambling.
Feng S, Dang S, Han TW, Ye W, Jin P, Cheng T, Li J, Jan YN, Jan LY, Cheng Y
Cell Rep 28 567-579.e4 (2019)
PMID: 31291589
Related structures: EMD-20244

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-180136 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Anoctamin-6 Chains: A, B
Molecule details ›
Chains: A, B
Length: 911 amino acids
Theoretical weight: 106.37 KDa
Source organism: Mus musculus
Expression system: Homo sapiens
UniProt:
  • Canonical: Q6P9J9 (Residues: 1-911; Coverage: 100%)
Gene names: Ano6, Tmem16f
Sequence domains:

Ligands and Environments

1 bound ligand:
Ligand CA 2 x CA
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.5Å
Relevant EMDB volumes: EMD-20244
Expression system: Homo sapiens

Quick links

Citations

11 review citations

Recent progress in structural studies on TMEM16A channel.
Shi et al. (2020)
10 more

6 mentions without citation

Reconstitution of ATP-dependent lipid transporters: gaining insight into molecular characteristics, regulation, and mechanisms.
Herrera et al. (2023)
5 more