› 6p5s

X-ray diffraction
2.19Å resolution

HIPK2 kinase domain bound to CX-4945

Released:
DOI: 10.2210/pdb6p5s/pdb
PDB entry 6p5s coloured by chain, front view.
PDB entry 6p5s coloured by chain, side view.
PDB entry 6p5s coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
The crystal structure of the protein kinase HIPK2 reveals a unique architecture of its CMGC-insert region.
Agnew C, Liu L, Liu S, Xu W, You L, Yeung W, Kannan N, Jablons D, Jura N
J Biol Chem 294 13545-13559 (2019)
PMID: 31341017

Function and Biology Details

Reaction catalysed: 
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-190562 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Homeodomain-interacting protein kinase 2 Chain: A
Molecule details ›
Chain: A
Length: 390 amino acids
Theoretical weight: 44.98 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9H2X6 (Residues: 177-547; Coverage: 31%)
Gene name: HIPK2
Sequence domains: Protein kinase domain

Ligands and Environments

1 bound ligand:
Ligand 3NG 1 x 3NG
2 modified residues:
Ligand PTR 1 x PTR
Ligand SEP 1 x SEP

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 8.3.1
Spacegroup: P62
Unit cell:
a: 130.155Å b: 130.155Å c: 52.253Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.2 0.198 0.238
Expression system: Escherichia coli

Quick links

Citations

2 review citations

HIPK2 in the physiology of nervous system and its implications in neurological disorders.
Sardina et al. (2023)
1 more

5 mentions without citation

Emerging roles of the αC-β4 loop in protein kinase structure, function, evolution, and disease.
Yeung et al. (2020)
4 more