› 6p7j

X-ray diffraction
3.5Å resolution

Crystal structure of Latency Associated Peptide unbound to TGF-beta1

Released:
DOI: 10.2210/pdb6p7j/pdb
PDB entry 6p7j coloured by chain, front view.
PDB entry 6p7j coloured by chain, side view.
PDB entry 6p7j coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural insights into conformational switching in latency-associated peptide between transforming growth factor beta-1 bound and unbound states
Stachowski TR, Snell ME, Snell EH
IUCrJ 7 238-252 (2020)

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-134058 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Latency-associated peptide Chain: A
Molecule details ›
Chain: A
Length: 255 amino acids
Theoretical weight: 29.27 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P01137 (Residues: 30-278; Coverage: 69%)
Gene names: TGFB, TGFB1
Sequence domains: TGF-beta propeptide

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 17-ID
Spacegroup: C222
Unit cell:
a: 51.06Å b: 154.9Å c: 62.25Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.29 0.288 0.322
Expression system: Homo sapiens

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