Function and Biology Details
Reaction catalysed:
Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
- Herpesvirus major capsid protein
- Herpesvirus capsid protein 2
- Gammaherpesvirus capsid
- Herpesvirus large tegument protein, USP domain
- Herpesvirus UL25
- Herpesvirus major capsid protein, upper domain superfamily
- Herpesvirus capsid shell protein 1
- Papain-like cysteine peptidase superfamily
2 more domains
Structure analysis Details
Assembly composition:
hetero nonadecamer (preferred)
PDBe Complex ID:
PDB-CPX-123549 (preferred)
Entry contents:
7 distinct polypeptide molecules
Macromolecules (7 distinct):
Capsid vertex component 1
Molecule details ›
Chain: k
Length: 454 amino acids
Theoretical weight: 49.59 KDa
Source organism: Human herpesvirus 8 strain GK18
UniProt:
Sequence domains: Herpesvirus UL17 protein
Length: 454 amino acids
Theoretical weight: 49.59 KDa
Source organism: Human herpesvirus 8 strain GK18
UniProt:
- Canonical:
F5HB39 (Residues: 1-454; Coverage: 100%)
Sequence domains: Herpesvirus UL17 protein
Capsid vertex component 2
Molecule details ›
Chains: l, m
Length: 549 amino acids
Theoretical weight: 61.49 KDa
Source organism: Human herpesvirus 8 strain GK18
UniProt:
Sequence domains: Herpesvirus UL25 family
Length: 549 amino acids
Theoretical weight: 61.49 KDa
Source organism: Human herpesvirus 8 strain GK18
UniProt:
- Canonical: Q2HRB3 (Residues: 1-549; Coverage: 100%)
Sequence domains: Herpesvirus UL25 family
Large tegument protein deneddylase
Molecule details ›
Chains: n, o
Length: 2635 amino acids
Theoretical weight: 290.02 KDa
Source organism: Human herpesvirus 8 strain GK18
UniProt:
Sequence domains: Herpesvirus tegument protein, N-terminal conserved region
Length: 2635 amino acids
Theoretical weight: 290.02 KDa
Source organism: Human herpesvirus 8 strain GK18
UniProt:
- Canonical: Q2HR64 (Residues: 1-2635; Coverage: 100%)
Sequence domains: Herpesvirus tegument protein, N-terminal conserved region
Major capsid protein
Molecule details ›
Chains: S, T, W, X
Length: 1376 amino acids
Theoretical weight: 153.57 KDa
Source organism: Human herpesvirus 8 strain GK18
UniProt:
Sequence domains: Herpes virus major capsid protein
Length: 1376 amino acids
Theoretical weight: 153.57 KDa
Source organism: Human herpesvirus 8 strain GK18
UniProt:
- Canonical: Q2HRA7 (Residues: 1-1376; Coverage: 100%)
Sequence domains: Herpes virus major capsid protein
Triplex capsid protein 1
Molecule details ›
Chains: 5, b
Length: 331 amino acids
Theoretical weight: 36.37 KDa
Source organism: Human herpesvirus 8 strain GK18
UniProt:
Sequence domains: Herpesvirus capsid shell protein VP19C
Length: 331 amino acids
Theoretical weight: 36.37 KDa
Source organism: Human herpesvirus 8 strain GK18
UniProt:
- Canonical: F5H8Y5 (Residues: 1-331; Coverage: 100%)
Sequence domains: Herpesvirus capsid shell protein VP19C
Triplex capsid protein 2
Molecule details ›
Chains: 6, 7, c, d
Length: 305 amino acids
Theoretical weight: 34.28 KDa
Source organism: Human herpesvirus 8 strain GK18
UniProt:
Sequence domains: Herpesvirus VP23 like capsid protein
Length: 305 amino acids
Theoretical weight: 34.28 KDa
Source organism: Human herpesvirus 8 strain GK18
UniProt:
- Canonical: F5HGN8 (Residues: 1-305; Coverage: 100%)
Sequence domains: Herpesvirus VP23 like capsid protein
Small capsomere-interacting protein
Molecule details ›
Chains: 0, 1, 2, 3
Length: 170 amino acids
Theoretical weight: 18.6 KDa
Source organism: Human herpesvirus 8 strain GK18
UniProt:
Sequence domains: Gammaherpesvirus capsid protein
Length: 170 amino acids
Theoretical weight: 18.6 KDa
Source organism: Human herpesvirus 8 strain GK18
UniProt:
- Canonical: Q2HR63 (Residues: 1-170; Coverage: 100%)
Sequence domains: Gammaherpesvirus capsid protein
