› 6pqo

Electron Microscopy
2.88Å resolution

Cryo-EM structure of the human TRPA1 ion channel in complex with the covalent agonist JT010

Released:
DOI: 10.2210/pdb6pqo/pdb
PDB entry 6pqo coloured by chain, front view.
PDB entry 6pqo coloured by chain, side view.
PDB entry 6pqo coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural Insights into Electrophile Irritant Sensing by the Human TRPA1 Channel.
Suo Y, Wang Z, Zubcevic L, Hsu AL, He Q, Borgnia MJ, Ji RR, Lee SY
Neuron 105 882-894.e5 (2020)
PMID: 31866091
Related structures: EMD-20449

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-131116 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecules (2 distinct):
Transient receptor potential cation channel subfamily A member 1 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 1152 amino acids
Theoretical weight: 131.5 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: O75762 (Residues: 2-1119; Coverage: 100%)
Gene names: ANKTM1, TRPA1
Sequence domains:

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG
Carbohydrate polymer
3 bound ligands:
Ligand JT0 4 x JT0
Ligand LBN 8 x LBN
Ligand 6OU 16 x 6OU
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 2.88Å
Relevant EMDB volumes: EMD-20449
Expression system: Homo sapiens

Quick links

Citations

9 review citations

Ca2+ signals in plant immunity.
Köster et al. (2022)
8 more

14 mentions without citation

Structural Pharmacology of TRP Channels.
Zhao et al. (2021)
13 more