› 6qdz

X-ray diffraction
1.73Å resolution

P38 alpha complex with AR117045

Released:
DOI: 10.2210/pdb6qdz/pdb
PDB entry 6qdz coloured by chain, front view.
PDB entry 6qdz coloured by chain, side view.
PDB entry 6qdz coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Brown DG, Hurley C, Irving SL

Function and Biology Details

Reaction catalysed: 
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-172487 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Mitogen-activated protein kinase 14 Chain: A
Molecule details ›
Chain: A
Length: 362 amino acids
Theoretical weight: 41.49 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q16539 (Residues: 1-360; Coverage: 100%)
Gene names: CSBP, CSBP1, CSBP2, CSPB1, MAPK14, MXI2, SAPK2A
Sequence domains: Protein kinase domain

Ligands and Environments

2 bound ligands:
Ligand I46 1 x I46
Ligand HYK 1 x HYK
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I04-1
Spacegroup: P212121
Unit cell:
a: 65.351Å b: 73.99Å c: 77.671Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.206 0.203 0.246
Expression system: Escherichia coli BL21(DE3)

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