› 6qi4

X-ray diffraction
1.78Å resolution

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-158585 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Neuronal calcium sensor 1 Chains: B, C
Molecule details ›
Chains: B, C
Length: 190 amino acids
Theoretical weight: 21.9 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P62166 (Residues: 1-190; Coverage: 100%)
Gene names: FLUP, FREQ, NCS1
Sequence domains:

Ligands and Environments

7 bound ligands:
Ligand CA 6 x CA
Ligand P6G 2 x P6G
Ligand NA 2 x NA
Ligand DMS 1 x DMS
Ligand ACT 1 x ACT
Ligand 1PE 5 x 1PE
Ligand FKW 1 x FKW
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALBA BEAMLINE XALOC
Spacegroup: P21
Unit cell:
a: 53.729Å b: 55.603Å c: 77.725Å
α: 90° β: 94.97° γ: 90°
R-values:
R R work R free
0.214 0.214 0.232
Expression system: Escherichia coli

Quick links

Citations

2 review citations

Protein-Directed Dynamic Combinatorial Chemistry: An Efficient Strategy in Drug Design.
Canal-Martín et al. (2020)
1 more

3 mentions without citation

Insights into real-time chemical processes in a calcium sensor protein-directed dynamic library.
Canal-Martín et al. (2019)
2 more