› 6qjq

Electron Microscopy
3.7Å resolution

Cryo-EM structure of heparin-induced 2N3R tau filaments

Released:
DOI: 10.2210/pdb6qjq/pdb
PDB entry 6qjq coloured by chain, front view.
PDB entry 6qjq coloured by chain, side view.
PDB entry 6qjq coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Heparin-induced tau filaments are polymorphic and differ from those in Alzheimer's and Pick's diseases.
Zhang W, Falcon B, Murzin AG, Fan J, Crowther RA, Goedert M, Scheres SH
Elife 8 (2019)
PMID: 30720432
Related structures: EMD-4566

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo hexamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-145403 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Microtubule-associated protein tau Chains: A, B, C, D, E, F
Molecule details ›
Chains: A, B, C, D, E, F
Length: 28 amino acids
Theoretical weight: 2.97 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P10636 (Residues: 620-647; Coverage: 4%)
Gene names: MAPT, MAPTL, MTBT1, TAU
Sequence domains: Tau and MAP protein, tubulin-binding repeat

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.7Å
Relevant EMDB volumes: EMD-4566
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

56 review citations

Protein transmission in neurodegenerative disease.
Peng et al. (2020)
55 more

7 mentions without citation

Prion-like strain effects in tauopathies.
Han et al. (2023)
6 more