› 6qyp

X-ray diffraction
2.2Å resolution

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-170534 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Induced myeloid leukemia cell differentiation protein Mcl-1 Chain: A
Molecule details ›
Chain: A
Length: 170 amino acids
Theoretical weight: 19.49 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q07820 (Residues: 171-327; Coverage: 45%)
Gene names: BCL2L3, MCL1
Sequence domains: Apoptosis regulator proteins, Bcl-2 family

Ligands and Environments

1 bound ligand:
Ligand JL5 1 x JL5
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I03
Spacegroup: P6522
Unit cell:
a: 40.165Å b: 40.165Å c: 327.8Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.201 0.198 0.253
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

10 review citations

The manipulation of apoptosis for cancer therapy using BH3-mimetic drugs.
Diepstraten et al. (2022)
9 more