› 6qzj

X-ray diffraction
2.2Å resolution

Crystal structure of human Aquaporin 7 at 2.2 A resolution

Released:
DOI: 10.2210/pdb6qzj/pdb
PDB entry 6qzj coloured by chain, front view.
PDB entry 6qzj coloured by chain, side view.
PDB entry 6qzj coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural Basis for Glycerol Efflux and Selectivity of Human Aquaporin 7.
de Maré SW, Venskutonytė R, Eltschkner S, de Groot BL, Lindkvist-Petersson K
Structure 28 215-222.e3 (2020)
PMID: 31831212

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-126992 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Aquaporin-7 Chain: A
Molecule details ›
Chain: A
Length: 247 amino acids
Theoretical weight: 26.77 KDa
Source organism: Homo sapiens
Expression system: Komagataella pastoris
UniProt:
  • Canonical: O14520 (Residues: 33-279; Coverage: 72%)
Gene names: AQP7, AQP7L, AQP9
Sequence domains: Major intrinsic protein

Ligands and Environments

2 bound ligands:
Ligand GOL 11 x GOL
Ligand PO4 2 x PO4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: PETRA III, EMBL c/o DESY BEAMLINE P13 (MX1)
Spacegroup: I4
Unit cell:
a: 86.761Å b: 86.761Å c: 83.544Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.21 0.209 0.243
Expression system: Komagataella pastoris

Quick links

Citations

3 review citations

Aquaglyceroporin Modulators as Emergent Pharmacological Molecules for Human Diseases.
Pimpão et al. (2022)
2 more

3 mentions without citation

Relevance of Aquaporins for Gamete Function and Cryopreservation.
Delgado-Bermúdez et al. (2022)
2 more