› 6r2l

X-ray diffraction
2.3Å resolution

NYBR1-A2-SLSKILDTV

Released:
DOI: 10.2210/pdb6r2l/pdb
PDB entry 6r2l coloured by chain, front view.
PDB entry 6r2l coloured by chain, side view.
PDB entry 6r2l coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Rizkallah PJ, Cole DK, Sami M

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero pentamer (preferred)
PDBe Complex ID:
PDB-CPX-100936 (preferred)
Entry contents:
5 distinct polypeptide molecules
Macromolecules (5 distinct):
HLA class I histocompatibility antigen, A alpha chain Chain: A
Molecule details ›
Chain: A
Length: 276 amino acids
Theoretical weight: 31.95 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P04439 (Residues: 25-299; Coverage: 81%)
Gene names: HLA-A, HLAA
Sequence domains:
Beta-2-microglobulin Chain: B
Molecule details ›
Chain: B
Length: 100 amino acids
Theoretical weight: 11.88 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P61769 (Residues: 21-119; Coverage: 100%)
Gene names: B2M, CDABP0092, HDCMA22P
Sequence domains: Immunoglobulin C1-set domain
Ankyrin repeat domain-containing protein 30A Chain: C
Molecule details ›
Chain: C
Length: 9 amino acids
Theoretical weight: 976 Da
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: Q9BXX3 (Residues: 960-968; Coverage: 1%)
Gene name: ANKRD30A
Ig-like domain-containing protein; T cell receptor alpha variable 22 Chain: D
Molecule details ›
Chain: D
Length: 194 amino acids
Theoretical weight: 21.68 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: K7N5M3 (Residues: 3-3, 118-198; Coverage: 37%)
  • Canonical: A0A0B4J277 (Residues: 21-109; Coverage: 99%)
Gene names: B2M, HDCMA22P, TRAV22
Sequence domains:
Ig-like domain-containing protein; T cell receptor beta variable 11-2 Chain: E
Molecule details ›
Chain: E
Length: 247 amino acids
Theoretical weight: 27.89 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: K7N5M4 (Residues: 5-5, 107-249; Coverage: 56%)
  • Canonical: A0A584 (Residues: 22-114; Coverage: 99%)
Gene names: B2M, HDCMA22P, TCRBV21S3A2N2T, TRBV11-2
Sequence domains:

Ligands and Environments

5 bound ligands:
Ligand PEG 1 x PEG
Ligand EDO 2 x EDO
Ligand GOL 3 x GOL
Ligand SO4 8 x SO4
Ligand EPE 1 x EPE
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I04-1
Spacegroup: P21
Unit cell:
a: 52.21Å b: 99.33Å c: 111.44Å
α: 90° β: 90.5° γ: 90°
R-values:
R R work R free
0.217 0.214 0.265
Expression systems:
  • Escherichia coli
  • Not provided

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