› 6r7y

Electron Microscopy
4.2Å resolution

CryoEM structure of calcium-bound human TMEM16K / Anoctamin 10 in detergent (low Ca2+, closed form)

Released:
DOI: 10.2210/pdb6r7y/pdb
PDB entry 6r7y coloured by chain, front view.
PDB entry 6r7y coloured by chain, side view.
PDB entry 6r7y coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
The structural basis of lipid scrambling and inactivation in the endoplasmic reticulum scramblase TMEM16K.
Bushell SR, Pike ACW, Falzone ME, Rorsman NJG, Ta CM, Corey RA, Newport TD, Christianson JC, Scofano LF, Shintre CA, Tessitore A, Chu A, Wang Q, Shrestha L, Mukhopadhyay SMM, Love JD, Burgess-Brown NA, Sitsapesan R, Stansfeld PJ, Huiskonen JT, Tammaro P, Accardi A, Carpenter EP
Nat Commun 10 3956 (2019)
PMID: 31477691
Related structures: EMD-4747

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domain:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-192646 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Anoctamin-10 Chains: A, B
Molecule details ›
Chains: A, B
Length: 667 amino acids
Theoretical weight: 77.28 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q9NW15 (Residues: 1-660; Coverage: 100%)
Gene names: ANO10, TMEM16K
Sequence domains: Calcium-activated chloride channel

Ligands and Environments

1 bound ligand:
Ligand CA 6 x CA
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 4.2Å
Relevant EMDB volumes: EMD-4747
Expression system: Spodoptera frugiperda

Quick links

Citations

19 review citations

Recent progress in structural studies on TMEM16A channel.
Shi et al. (2020)
18 more