› 6r9t

Electron Microscopy
6.2Å resolution

Cryo-EM structure of autoinhibited human talin-1

Released:
DOI: 10.2210/pdb6r9t/pdb
PDB entry 6r9t coloured by chain, front view.
PDB entry 6r9t coloured by chain, side view.
PDB entry 6r9t coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
The Architecture of Talin1 Reveals an Autoinhibition Mechanism.
Dedden D, Schumacher S, Kelley CF, Zacharias M, Biertümpfel C, Fässler R, Mizuno N
Cell 179 120-131.e13 (2019)
PMID: 31539492
Related structures: EMD-4772

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-195227 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Talin-1 Chain: A
Molecule details ›
Chain: A
Length: 2547 amino acids
Theoretical weight: 270.77 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q9Y490 (Residues: 1-2541; Coverage: 100%)
Gene names: KIAA1027, TLN, TLN1
Sequence domains:

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 6.2Å
Relevant EMDB volumes: EMD-4772
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

14 review citations

Initiation of focal adhesion assembly by talin and kindlin: A dynamic view.
Zhu et al. (2021)
13 more

10 mentions without citation

Structural Basis of β2 Integrin Inside-Out Activation.
Wen et al. (2022)
9 more