Function and Biology Details
Reaction catalysed:
DNA (containing 4-O-methylthymine) + protein L-cysteine = DNA (without 4-O-methylthymine) + protein S-methyl-L-cysteine
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure analysis Details
Assembly composition:
hetero tetradecamer (preferred)
PDBe Complex ID:
PDB-CPX-109150 (preferred)
Entry contents:
6 distinct polypeptide molecules
Macromolecules (6 distinct):
Cytoplasmic dynein 2 heavy chain 1; Methylated-DNA--protein-cysteine methyltransferase
Molecule details ›
Chains: A, B
Length: 4513 amino acids
Theoretical weight: 515.22 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
Length: 4513 amino acids
Theoretical weight: 515.22 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
- Canonical:
E5BBQ0 (Residues: 5-181; Coverage: 97%) - Canonical: B0I1S0 (Residues: 2-4307; Coverage: 100%)
- 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain
- 6-O-methylguanine DNA methyltransferase, DNA binding domain
- Dynein heavy chain, N-terminal region 1
- Dynein heavy chain, N-terminal region 2
- Hydrolytic ATP binding site of dynein motor region
- Cytoplasmic dynein 2 heavy chain 1, AAA+ ATPase domain
- P-loop containing dynein motor region
- P-loop containing dynein motor region D4
- Microtubule-binding stalk of dynein motor
- ATP-binding dynein motor region
- Dynein heavy chain region D6 P-loop domain
- Dynein heavy chain AAA lid domain
- Dynein heavy chain C-terminal domain
Cytoplasmic dynein 2 intermediate chain 1
Molecule details ›
Chain: C
Length: 1066 amino acids
Theoretical weight: 122.87 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
Length: 1066 amino acids
Theoretical weight: 122.87 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
- Canonical: Q8WVS4 (Residues: 1-1066; Coverage: 100%)
Cytoplasmic dynein 2 intermediate chain 2
Molecule details ›
Chain: D
Length: 564 amino acids
Theoretical weight: 60.77 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
Sequence domains: WD domain, G-beta repeat
Length: 564 amino acids
Theoretical weight: 60.77 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
- Canonical: Q96EX3 (Residues: 1-536; Coverage: 100%)
Sequence domains: WD domain, G-beta repeat
Cytoplasmic dynein 2 light intermediate chain 1
Molecule details ›
Chains: E, F
Length: 351 amino acids
Theoretical weight: 39.68 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
Sequence domains: Dynein light intermediate chain (DLIC)
Length: 351 amino acids
Theoretical weight: 39.68 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
- Canonical: Q8TCX1 (Residues: 1-351; Coverage: 100%)
Sequence domains: Dynein light intermediate chain (DLIC)
Dynein light chain roadblock-type 1
Molecule details ›
Chains: G, H
Length: 96 amino acids
Theoretical weight: 10.93 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
Sequence domains: Roadblock/LC7 domain
Length: 96 amino acids
Theoretical weight: 10.93 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
- Canonical: Q9NP97 (Residues: 1-96; Coverage: 100%)
Sequence domains: Roadblock/LC7 domain
Dynein light chain 1, cytoplasmic
Molecule details ›
Chains: I, J, K, L, M, N
Length: 89 amino acids
Theoretical weight: 10.38 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
Sequence domains: Dynein light chain type 1
Length: 89 amino acids
Theoretical weight: 10.38 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
- Canonical: P63167 (Residues: 1-89; Coverage: 100%)
Sequence domains: Dynein light chain type 1
