› 6rlr

X-ray diffraction
2Å resolution

Crystal structure of CD9 large extracellular loop

Released:
DOI: 10.2210/pdb6rlr/pdb
PDB entry 6rlr coloured by chain, front view.
PDB entry 6rlr coloured by chain, side view.
PDB entry 6rlr coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Implications for tetraspanin-enriched microdomain assembly based on structures of CD9 with EWI-F.
Oosterheert W, Xenaki KT, Neviani V, Pos W, Doulkeridou S, Manshande J, Pearce NM, Kroon-Batenburg LM, Lutz M, van Bergen En Henegouwen PM, Gros P
Life Sci Alliance 3 (2020)
PMID: 32958604

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-149478 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
CD9 antigen Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 90 amino acids
Theoretical weight: 10.26 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P21926 (Residues: 114-191; Coverage: 34%)
Gene names: CD9, GIG2, MIC3, TSPAN29
Sequence domains: Tetraspanin family

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I04
Spacegroup: P1
Unit cell:
a: 39.986Å b: 39.998Å c: 63.643Å
α: 80.39° β: 76.29° γ: 68.15°
R-values:
R R work R free
0.241 0.239 0.279
Expression system: Homo sapiens

Quick links

Citations

4 review citations

CD9, a tetraspanin target for cancer therapy?
Lorico et al. (2021)
3 more

4 mentions without citation

Implications for tetraspanin-enriched microdomain assembly based on structures of CD9 with EWI-F.
Oosterheert et al. (2020)
3 more