› 6rol

X-ray diffraction
2.1Å resolution

Structure of IMP2 KH34 domains

Released:
DOI: 10.2210/pdb6rol/pdb
PDB entry 6rol coloured by chain, front view.
PDB entry 6rol coloured by chain, side view.
PDB entry 6rol coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
The structural basis for RNA selectivity by the IMP family of RNA-binding proteins.
Biswas J, Patel VL, Bhaskar V, Chao JA, Singer RH, Eliscovich C
Nat Commun 10 4440 (2019)
PMID: 31570709

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-195373 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Insulin-like growth factor 2 mRNA-binding protein 2 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 166 amino acids
Theoretical weight: 18.2 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9Y6M1 (Residues: 426-588; Coverage: 27%)
Gene names: IGF2BP2, IMP2, VICKZ2
Sequence domains: KH domain

Ligands and Environments

3 bound ligands:
Ligand GOL 18 x GOL
Ligand PEG 10 x PEG
Ligand SO4 4 x SO4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 18-ID
Spacegroup: P21
Unit cell:
a: 76.88Å b: 62.38Å c: 85.74Å
α: 90° β: 91.32° γ: 90°
R-values:
R R work R free
0.198 0.198 0.224
Expression system: Escherichia coli

Quick links

Citations

4 review citations

RNA packaging into extracellular vesicles: An orchestra of RNA-binding proteins?
Fabbiano et al. (2020)
3 more

5 mentions without citation

Characterization of epitranscriptome reader proteins experimentally and in silico: Current knowledge and future perspectives beyond the YTH domain.
Miller et al. (2023)
4 more